2. GPCR/G Protein Neuronal Signaling Metabolic Enzyme/Protease
  3. Neurokinin Receptor Endogenous Metabolite
  4. Substance P TFA

Substance P TFA  (Synonyms: Neurokinin P TFA)

Cat. No.: HY-P0201A Purity: 99.79%
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Substance P TFA (Neurokinin P TFA) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R).

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Substance P TFA Chemical Structure

Substance P TFA Chemical Structure

CAS No. : 148470-19-3

Size Price Stock Quantity
1 mg USD 60 In-stock
5 mg USD 132 In-stock
10 mg USD 240 In-stock
25 mg USD 450 In-stock
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100 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

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Based on 16 publication(s) in Google Scholar

Other Forms of Substance P TFA:

Substance P TFA Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

Substance P TFA (Neurokinin P TFA) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R)[1].

IC50 & Target

NK1

 

Human Endogenous Metabolite

 

In Vitro

The neuropeptide substance P (SP) that are mediated by the neurokinin 1 receptor (NK1-R) desensitize and resensitize, which may be associated with NK1-R endocytosis and recycling. SP and the NK1-R are internalized into the same clathrin immunoreactive vesicles, and then sorted into different compartments. SP is intact at the cell surface and in early endosomes, but slowly degraded in perinuclear vesicles. SP induces clathrin-dependent internalization of the NK1-R. The SP/NK1-R complex dissociates in acidified endosomes. SP is degraded, whereas the NK1-R recycles to the cell surface. SP induces internalization of the NK1-R both in transfected epithelial cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Substance P TFA Related Antibodies
Clinical Trial
Molecular Weight

1461.65

Formula

C65H99F3N18O15S
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2
Sequence Shortening

RPKPQQFFGLM-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Stored under nitrogen, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (68.42 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6842 mL 3.4208 mL 6.8416 mL
5 mM 0.1368 mL 0.6842 mL 1.3683 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (34.21 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.6842 mL 3.4208 mL 6.8416 mL 17.1040 mL
5 mM 0.1368 mL 0.6842 mL 1.3683 mL 3.4208 mL
10 mM 0.0684 mL 0.3421 mL 0.6842 mL 1.7104 mL
15 mM 0.0456 mL 0.2281 mL 0.4561 mL 1.1403 mL
20 mM 0.0342 mL 0.1710 mL 0.3421 mL 0.8552 mL
25 mM 0.0274 mL 0.1368 mL 0.2737 mL 0.6842 mL
30 mM 0.0228 mL 0.1140 mL 0.2281 mL 0.5701 mL
40 mM 0.0171 mL 0.0855 mL 0.1710 mL 0.4276 mL
50 mM 0.0137 mL 0.0684 mL 0.1368 mL 0.3421 mL
60 mM 0.0114 mL 0.0570 mL 0.1140 mL 0.2851 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Substance P TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Substance P148470-19-3Neurokinin PNeurokinin ReceptorEndogenous MetaboliteNK receptorTachykinin receptorInhibitorinhibitorinhibit

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