2. GPCR/G Protein Neuronal Signaling
  3. Somatostatin Receptor
  4. Cortistatin-14

Cortistatin-14, a neuropeptide have structural similarity to somatostatin-14, binds and exerts its function via the somatostatin receptors (sst1-sst5). Cortistatin-14 shows anticonvulsive, neuroprotective effect and remarkable anti-inflammatory properties.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Cortistatin-14 Chemical Structure

Cortistatin-14 Chemical Structure

CAS No. : 186901-48-4

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500 μg USD 65 In-stock
1 mg USD 120 In-stock
5 mg USD 480 In-stock
10 mg USD 860 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Cortistatin-14:

Cortistatin-14 Related Antibodies

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  • Biological Activity

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Description

Cortistatin-14, a neuropeptide have structural similarity to somatostatin-14, binds and exerts its function via the somatostatin receptors (sst1-sst5). Cortistatin-14 shows anticonvulsive, neuroprotective effect and remarkable anti-inflammatory properties[1][2][3][4].

Molecular Weight

1720.03

Formula

C81H114N20O18S2
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

{Pro}{Cys}{Lys}{Asn}{Phe}{Phe}{Trp}{Lys}{Thr}{Phe}{Ser}{Ser}{Cys}{Lys}-NH2 (Disulfide bridge: Cys2-Cys13)
Sequence Shortening

PCKNFFWKTFSSCK-NH2 (Disulfide bridge: Cys2-Cys13)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (58.14 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.5814 mL 2.9069 mL 5.8139 mL
5 mM 0.1163 mL 0.5814 mL 1.1628 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (58.14 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.5814 mL 2.9069 mL 5.8139 mL 14.5346 mL
5 mM 0.1163 mL 0.5814 mL 1.1628 mL 2.9069 mL
10 mM 0.0581 mL 0.2907 mL 0.5814 mL 1.4535 mL
15 mM 0.0388 mL 0.1938 mL 0.3876 mL 0.9690 mL
20 mM 0.0291 mL 0.1453 mL 0.2907 mL 0.7267 mL
25 mM 0.0233 mL 0.1163 mL 0.2326 mL 0.5814 mL
30 mM 0.0194 mL 0.0969 mL 0.1938 mL 0.4845 mL
40 mM 0.0145 mL 0.0727 mL 0.1453 mL 0.3634 mL
50 mM 0.0116 mL 0.0581 mL 0.1163 mL 0.2907 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Cortistatin-14 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cortistatin-14186901-48-4Cortistatin14Cortistatin 14Somatostatin ReceptorSSTRsSSTRInhibitorinhibitorinhibit

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