186901-48-4
Chemical Structure
Cortistatin-14
- No. CAS: 186901-48-4
- Formula:C81H114N20O18S2
- Molecular Weight:1720.03
IUPAC Name: (4R,7S,10S,13S,16S,19S,22S,25S,28S,31S,34S,37R)-22-((1H-indol-3-yl)methyl)-31-(2-amino-2-oxoethyl)-19,34-bis(4-aminobutyl)-13,25,28-tribenzyl-N-((S)-1,6-diamino-1-oxohexan-2-yl)-16-((R)-1-hydroxyethyl)-7,10-bis(hydroxymethyl)-6,9,12,15,18,21,24,27,30,33,3
InChIKey: WAJOXVQGVNYWIO-WYYADCIBSA-N
SMILES: O=C(N[C@H]1CC2=CNC3=CC=CC=C23)[C@H](CC4=CC=CC=C4)NC([C@H](CC5=CC=CC=C5)NC([C@H](CC(N)=O)NC([C@H](CCCCN)NC([C@@H](NC([C@@H]6CCCN6)=O)CSSC[C@@H](C(N[C@@H](CCCCN)C(N)=O)=O)NC([C@H](CO)NC([C@H](CO)NC([C@H](CC7=CC=CC=C7)NC([C@]([H])([C@@H](C)O)NC([C@H](CCCCN)NC1=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Biological Activity: Cortistatin-14 is a neuropeptide that shares structural similarities with somatostatin, working by binding to somatostatin receptors (sst1-sst5). Cortistatin-14 (TFA) has anticonvulsant, neuroprotective effects, and significant anti-inflammatory properties[1][2][3].
| Referencia número | Nombre del producto | Pureza | Descripciòn | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Cortistatin-14 | 99.65% | Cortistatin-14 is a neuropeptide that shares structural similarities with somatostatin, working by binding to somatostatin receptors (sst1-sst5). Cortistatin-14 (TFA) has anticonvulsant, neuroprotective effects, and significant anti-inflammatory properties. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Markovics A, et al. Comparison of the anti-inflammatory and anti-nociceptive effects of cortistatin-14 and somatostatin-14 in distinct in vitro and in vivo model systems. J Mol Neurosci. 2012 Jan;46(1):40-50. [Content Brief]
- [2]. Baranowska B, et al. Cortistatin and pituitary hormone secretion in rat. J Physiol Pharmacol. 2009 Mar;60(1):151-6. [Content Brief]
- [3]. Braun H, et al. Protective effects of cortistatin (CST-14) against kainate-induced neurotoxicity in rat brain. Brain Res. 1998 Aug 24;803(1-2):54-60. [Content Brief]
