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  3. Cyclic somatostatin

Cyclic somatostatin  (Synonyms: SRIF-14; Somatostatin-14)

Cat. No.: HY-P0084 Purity: 99.77%
COA Handling Instructions

Cyclic somatostatin (SRIF-14) is a growth hormone-release inhibiting factor used in the research of severe, acute hemorrhages of gastroduodenal ulcers. Cyclic somatostatin is a neuropeptide co-stored with acetylcholine in the cardiac parasympathetic innervation, exerts influences directly on contraction of ventricular cardiomyocytes. Cyclic somatostatin inhibits the contractile response of isoprenaline with an IC50 value of 13 nM. Cyclic somatostatin can be used for the research of cardiovascular disease.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Cyclic somatostatin Chemical Structure

Cyclic somatostatin Chemical Structure

CAS No. : 38916-34-6

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Based on 1 publication(s) in Google Scholar

Cyclic somatostatin Related Antibodies

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Description

Cyclic somatostatin (SRIF-14) is a growth hormone-release inhibiting factor used in the research of severe, acute hemorrhages of gastroduodenal ulcers. Cyclic somatostatin is a neuropeptide co-stored with acetylcholine in the cardiac parasympathetic innervation, exerts influences directly on contraction of ventricular cardiomyocytes. Cyclic somatostatin inhibits the contractile response of isoprenaline with an IC50 value of 13 nM. Cyclic somatostatin can be used for the research of cardiovascular disease[1][2][3].

IC50 & Target

IC50: 13 nM (contractile response of isoprenaline)[1]
In Vitro

Cyclic somatostatin (0-10 μM; 15 min) dose-dependently inhibits the contractile response to isoprenaline in rat ventricular cardiomyocytes with an IC50 value of? 13 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cyclic somatostatin Related Antibodies
In Vivo

Cyclic somatostatin (5 μg/kg; i.v. per hour once for 18-22 hours) affects visceral metabolism in ruminants[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Polypay sheeps[3]
Dosage: 5 μg/kg
Administration: Intravenous injection; 5 μg/kg per hour once; for 18-22 hours
Result: Decreased net portal-drained viscera release of glucose, a-amino N, ammonia N, b-hydrox ybutyrate, oxygen consumption, liver oxygen consumption, and total splanchnic a-amino N release and oxygen consumption. Increased lactate release and net hepatic glucose output.
Molecular Weight

1637.88

Appearance

Solid

Formula

C76H104N18O19S2
CAS No.
Sequence

Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys (Disulfide bridge: Cys3-Cys14)
Sequence Shortening

AGCKNFFWKTFTSC (Disulfide bridge: Cys3-Cys14)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (61.05 mM; Need ultrasonic)

DMF : 100 mg/mL (61.05 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6105 mL 3.0527 mL 6.1055 mL
5 mM 0.1221 mL 0.6105 mL 1.2211 mL
10 mM 0.0611 mL 0.3053 mL 0.6105 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation

Purity: 99.77%

COA (269 KB) LCMS (293 KB) Elemental Analysis Report (128 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Cyclic somatostatin38916-34-6SRIF-14 Somatostatin-14SRIF14SRIF 14Somatostatin14Somatostatin 14Somatostatin-14Othersgrowth hormonegastroduodenal ulcerneuropeptidecardiomyocytetetradecapeptidesheepmetabolismruminantInhibitorinhibitorinhibit

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