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  2. Cyclic somatostatin

Cyclic somatostatin  (Synonyms: SRIF-14; Somatostatin-14)

Cat. No.: HY-P0084 Purity: 99.77%
COA Handling Instructions

Cyclic somatostatin (SRIF-14) is a growth hormone-release inhibiting factor used in the research of severe, acute hemorrhages of gastroduodenal ulcers. Cyclic somatostatin is a neuropeptide co-stored with acetylcholine in the cardiac parasympathetic innervation, exerts influences directly on contraction of ventricular cardiomyocytes. Cyclic somatostatin inhibits the contractile response of isoprenaline with an IC50 value of 13 nM. Cyclic somatostatin can be used for the research of cardiovascular disease.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Cyclic somatostatin Chemical Structure

Cyclic somatostatin Chemical Structure

CAS No. : 38916-34-6

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1 mg USD 40 In-stock
5 mg USD 72 In-stock
10 mg USD 96 In-stock
25 mg USD 120 In-stock
50 mg USD 180 In-stock
100 mg USD 270 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Cyclic somatostatin (SRIF-14) is a growth hormone-release inhibiting factor used in the research of severe, acute hemorrhages of gastroduodenal ulcers. Cyclic somatostatin is a neuropeptide co-stored with acetylcholine in the cardiac parasympathetic innervation, exerts influences directly on contraction of ventricular cardiomyocytes. Cyclic somatostatin inhibits the contractile response of isoprenaline with an IC50 value of 13 nM. Cyclic somatostatin can be used for the research of cardiovascular disease[1][2][3].

IC50 & Target

IC50: 13 nM (contractile response of isoprenaline)[1]

In Vitro

Cyclic somatostatin (0-10 μM; 15 min) dose-dependently inhibits the contractile response to isoprenaline in rat ventricular cardiomyocytes with an IC50 value of? 13 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Cyclic somatostatin (5 μg/kg; i.v. per hour once for 18-22 hours) affects visceral metabolism in ruminants[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Polypay sheeps[3]
Dosage: 5 μg/kg
Administration: Intravenous injection; 5 μg/kg per hour once; for 18-22 hours
Result: Decreased net portal-drained viscera release of glucose, a-amino N, ammonia N, b-hydrox ybutyrate, oxygen consumption, liver oxygen consumption, and total splanchnic a-amino N release and oxygen consumption. Increased lactate release and net hepatic glucose output.
Molecular Weight

1637.88

Formula

C76H104N18O19S2

CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys (Disulfide bridge: Cys3-Cys14)

Sequence Shortening

AGCKNFFWKTFTSC (Disulfide bridge: Cys3-Cys14)

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 1 years; -20°C, 6 months (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (61.05 mM; Need ultrasonic)

DMF : 100 mg/mL (61.05 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6105 mL 3.0527 mL 6.1055 mL
5 mM 0.1221 mL 0.6105 mL 1.2211 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 years; -20°C, 6 months (sealed storage, away from moisture and light). When stored at -80°C, please use it within 1 years. When stored at -20°C, please use it within 6 months.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.77%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 years; -20°C, 6 months (sealed storage, away from moisture and light). When stored at -80°C, please use it within 1 years. When stored at -20°C, please use it within 6 months.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMF 1 mM 0.6105 mL 3.0527 mL 6.1055 mL 15.2636 mL
5 mM 0.1221 mL 0.6105 mL 1.2211 mL 3.0527 mL
10 mM 0.0611 mL 0.3053 mL 0.6105 mL 1.5264 mL
15 mM 0.0407 mL 0.2035 mL 0.4070 mL 1.0176 mL
20 mM 0.0305 mL 0.1526 mL 0.3053 mL 0.7632 mL
25 mM 0.0244 mL 0.1221 mL 0.2442 mL 0.6105 mL
30 mM 0.0204 mL 0.1018 mL 0.2035 mL 0.5088 mL
40 mM 0.0153 mL 0.0763 mL 0.1526 mL 0.3816 mL
50 mM 0.0122 mL 0.0611 mL 0.1221 mL 0.3053 mL
60 mM 0.0102 mL 0.0509 mL 0.1018 mL 0.2544 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Cyclic somatostatin
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HY-P0084
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