2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Cyclic somatostatin acetate

Cyclic somatostatin acetate  (Synonyms: SRIF-14 acetate; Somatostatin-14 acetate)

Cat. No.: HY-P0084A
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Cyclic somatostatin (SRIF-14) acetate is a growth hormone-release inhibiting factor used in the research of severe, acute hemorrhages of gastroduodenal ulcers. Cyclic somatostatin acetate is a neuropeptide co-stored with acetylcholine in the cardiac parasympathetic innervation, exerts influences directly on contraction of ventricular cardiomyocytes. Cyclic somatostatin acetate inhibits the contractile response of isoprenaline with an IC50 value of 13 nM. Cyclic somatostatin acetate can be used for the research of cardiovascular disease.

For research use only. We do not sell to patients.

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Cyclic somatostatin acetate

Cyclic somatostatin acetate Chemical Structure

CAS No. : 54472-66-1

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Cyclic somatostatin acetate Related Antibodies

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Description

Cyclic somatostatin (SRIF-14) acetate is a growth hormone-release inhibiting factor used in the research of severe, acute hemorrhages of gastroduodenal ulcers. Cyclic somatostatin acetate is a neuropeptide co-stored with acetylcholine in the cardiac parasympathetic innervation, exerts influences directly on contraction of ventricular cardiomyocytes. Cyclic somatostatin acetate inhibits the contractile response of isoprenaline with an IC50 value of 13 nM. Cyclic somatostatin acetate can be used for the research of cardiovascular disease[1][2][3].

In Vitro

Cyclic somatostatin (0-10 μM; 15 min) acetate dose-dependently inhibits the contractile response to isoprenaline in rat ventricular cardiomyocytes with an IC50 value of 13 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cyclic somatostatin acetate Related Antibodies
In Vivo

Cyclic somatostatin (5 μg/kg; i.v. per hour once for 18-22 hours) acetate affects visceral metabolism in ruminants[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Polypay sheeps[3]
Dosage: 5 μg/kg
Administration: Intravenous injection; 5 μg/kg per hour once; for 18-22 hours
Result: Decreased net portal-drained viscera release of glucose, a-amino N, ammonia N, b-hydrox ybutyrate, oxygen consumption, liver oxygen consumption, and total splanchnic a-amino N release and oxygen consumption. Increased lactate release and net hepatic glucose output.
Molecular Weight

1697.93

Formula

C78H108N18O21S2
CAS No.
Sequence

Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys (Disulfide bridge: Cys3-Cys14)
Sequence Shortening

AGCKNFFWKTFTSC-OH (Disulfide bridge: Cys3-Cys14)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Cyclic somatostatin acetate Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cyclic somatostatin54472-66-1SRIF-14Somatostatin-14SRIF14SRIF 14Somatostatin14Somatostatin 14Endogenous Metabolitegrowth hormonegastroduodenal ulcerneuropeptidecardiomyocytetetradecapeptidesheepmetabolismruminantInhibitorinhibitorinhibit

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