38916-34-6
Chemical Structure
Cyclic somatostatin
Synonym(s): SRIF-14; Somatostatin-14
- CAS No.: 38916-34-6
- Formula:C76H104N18O19S2
- Molecular Weight:1637.88
IUPAC Name: (4R,7S,10S,13S,16S,19S,22S,25S,28S,31S,34S,37R)-22-((1H-indol-3-yl)methyl)-31-(2-amino-2-oxoethyl)-19,34-bis(4-aminobutyl)-37-(2-((S)-2-aminopropanamido)acetamido)-13,25,28-tribenzyl-10,16-bis((R)-1-hydroxyethyl)-7-(hydroxymethyl)-6,9,12,15,18,21,24,27,30,33,36-undecaoxo-1,2-dithia-5,8,11,14,17,20,23,26,29,32,35-undecaazacyclooctatriacontane-4-carboxylic acid
InChIKey: NHXLMOGPVYXJNR-ATOGVRKGSA-N
SMILES: O=C([C@@H](N)C)NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]1CO)=O)[C@@H](C)O)=O)CC2=CC=CC=C2)=O)[C@@H](C)O)=O)CCCCN)=O)CC3=CNC4=CC=CC=C34)=O)CC5=CC=CC=C5)=O)CC6=CC=CC=C6)=O)CC(N)=O)=O)CCCCN)=O)CSSC[C@H](NC1=O)C(O)=O)=O
Biological Activity: Cyclic somatostatin (SRIF-14) is a growth hormone-release inhibiting factor used in the research of severe, acute hemorrhages of gastroduodenal ulcers. Cyclic somatostatin is a neuropeptide co-stored with acetylcholine in the cardiac parasympathetic innervation, exerts influences directly on contraction of ventricular cardiomyocytes. Cyclic somatostatin inhibits the contractile response of isoprenaline with an IC50 value of 13 nM. Cyclic somatostatin can be used for the research of cardiovascular disease[1][2][3].
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Cyclic somatostatin | 99.87% | Cyclic somatostatin (SRIF-14) is a growth hormone-release inhibiting factor used in the research of severe, acute hemorrhages of gastroduodenal ulcers. Cyclic somatostatin is a neuropeptide co-stored with acetylcholine in the cardiac parasympathetic innervation, exerts influences directly on contraction of ventricular cardiomyocytes. Cyclic somatostatin inhibits the contractile response of isoprenaline with an IC50 value of 13 nM. Cyclic somatostatin can be used for the research of cardiovascular disease. | ||||||||||||||||||||
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- [1]. Murray F, et al. Positive and negative contractile effects of somatostatin-14 on rat ventricular cardiomyocytes. J Cardiovasc Pharmacol. 2001 Mar;37(3):324-32. [Content Brief]
- [2]. Bell D, et al. SRIF receptor subtype expression and involvement in positive and negative contractile effects of somatostatin-14 (SRIF-14) in ventricular cardiomyocytes. Cell Physiol Biochem. 2008;22(5-6):653-64. [Content Brief]
- [3]. McLeod KR, et al. Effects of exogenous somatostatin and cysteamine on net nutrient flux across the portal-drained viscera and liver of sheep during intraduodenal infusion of starch hydrolysate and casein. J Anim Sci. 1997 Nov;75(11):3026-37. [Content Brief]
Keywords
