High affinity, selective neurokinin 2 and neurokinin 3 receptor antagonists from a common structural template
- Bioorg Med Chem Lett. 1998 Jun 2;8(11):1343-8. doi: 10.1016/s0960-894x(98)00215-7.
Affiliations
- 1. Department of Medicinal Chemistry, Merck Sharp Laboratory, Essex, U.K. [email protected]
PMID: 9871763
DOI: 10.1016/s0960-894x(98)00215-7
Abstract
High affinity, selective hNK2 or hNK3 ligands can be prepared from the common template 1 in a few simple chemical operations. The hNK3 ligands 3 antagonise the calcium mobilisation caused by activation of hNK3 receptors expressed in CHO cells as measured using fura-2 microspectrofluorimetry.
Products
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Cat. No.Product NameDescriptionTargetResearch Area
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target: Neurokinin Receptor
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target: Neurokinin ReceptorResearch Areas: Neurological Disease