1. GPCR/G Protein
    Neuronal Signaling
  2. Neurokinin Receptor

Senktide 

Cat. No.: HY-P0187 Purity: 99.56%
Handling Instructions

Senktide is a tachykinin NK3 receptor agonist.

For research use only. We do not sell to patients.

Senktide Chemical Structure

Senktide Chemical Structure

CAS No. : 106128-89-6

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Estimated Time of Arrival: December 31
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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Senktide is a tachykinin NK3 receptor agonist.

IC50 & Target

NK3 receptor[1]

In Vitro

The selective NK3 receptor agonist Senktide excites 24 of 31 dopaminergic neurons in the substantia nigra pars compacta in a concentration-dependent manner. The effective concentration range is between 3 to 3000 nm. The mean EC50 for Senktide is 41.2±9 nm (n=5)[2].

In Vivo

I.c.v. injection of Senktide causes a dose-dependent increase in total distance traveled (F6,72=6.344, P<0.001). This increase reaches statistical significance compare to the vehicle-treated group at 0.06 nmol and higher. The Senktide-induced increase in locomotor activity brought about by 0.1 nmol of Senktide is significantly and dose-dependently decreased by the tachykinin NK3 receptor antagonists talnetant at 30 mg/kg and SB222200 at 30 mg/kg, but not by osanetant, when tested in parallel in a single experiment (F7,78=10.32, P<0.001), although a non-significant reduction is observed. However, when tested using another vehicle (Vitamin E and glycofurol), osanetant does decrease activity significantly compare to Senktide-treated gerbils (F2,30=10.10, P<0.001)[1].

References
Cell Assay
[2]

Experiments are performed on brain slices (300 μM thick) from 150 g male Wistar rats and extracellular recordings are made by conventional techniques. Drugs (including Senktide) are applied by bath perfusion and removal is achieved simply by returning to the control drug-free solution. Extracellular electrodes are filled with aCSF and have resistances of 5 to 14 MΩ. For intracellular recordings, electrodes are filled with 1 M potassium acetate and have d.c. resistances of 70 to 110 MΩ. Neurons are considered to be dopaminergic if they have a characteristic waveform, slow firing rate (~5 Hz) and inhibitory response to dopamine[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration
[1]

For the Senktide dose-response curve, gerbils are first allowed to habituate to the test area for 30 min. Animals (n=10 to 12 per drug treatment group) are anesthetized with isoflurane, a small incision is made in the skin over bregma, and an injection of Senktide at 0.01, 0.03, 0.06, 0.1, 0.3 or 0.6 nmol in 5 μL of vehicle is placed i.c.v. using a syringe with a 4.5 mm long needle. Wounds are clipped shut, and animals allowed to awaken from anesthesia, then placed directly into the locomotor activity boxes and recording commenced. For testing of the NK1 receptor antagonist aprepitant (1, 3 or 10 mg/kg p.o.), gerbils are first treated with aprepitant or vehicle (0.9% NaCl with 0.3% Tween80) and returned to the home cage for 90 min. Animals are then placed in the open field for 30 min of habituation. During the last 5 min of habituation, 0.03 nmol Senktide is injected i.c.v[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

841.97

Formula

C₄₀H₅₅N₇O₁₁S

CAS No.

106128-89-6

Sequence

Suc-Asp-{Me-Phe}-Phe-Gly-Leu-Met-NH2

Sequence Shortening

Suc-D-{Me-Phe}-FGLM-NH2

SMILES

O=C(N(C)[[email protected]](C(NCC(N[[email protected]@H](CC(C)C)C(N[[email protected]](C(N)=O)CCSC)=O)=O)=O)CC1=CC=CC=C1)[[email protected]@H](NC([[email protected]](CC(O)=O)NC(CCC(O)=O)=O)=O)CC2=CC=CC=C2

Storage
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Senktide
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HY-P0187
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Senktide

Cat. No.: HY-P0187