1. Anti-infection
  2. Bacterial
  3. pBD-1 TFA

pBD-1 TFA 

Cat. No.: HY-P2289A
Handling Instructions

pBD-1 TFA is an endogenous and constitutively expressed antimicrobial peptide (AMP) from porcine tissues, particularly expresses in pig mucosal epithelial sites. pBD-1 TFA has antimicrobial activities and contributes to mucosal and systemic host defenses in pigs.

For research use only. We do not sell to patients.

pBD-1 TFA Chemical Structure

pBD-1 TFA Chemical Structure

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Description

pBD-1 TFA is an endogenous and constitutively expressed antimicrobial peptide (AMP) from porcine tissues, particularly expresses in pig mucosal epithelial sites. pBD-1 TFA has antimicrobial activities and contributes to mucosal and systemic host defenses in pigs[1].

IC50 & Target

IC50: bacterial[1]

In Vitro

In a northern blot analysis, pBD-1 TFA mRNA only expresses in ongue epithelial tissues from 4-5 week old pigs[1].
In RT-PCR analysis, pBD-1 TFA message throughout the epithelia of the respiratory (from nasal septum to lung) and gastrointestinal (from esophagus to rectum) tracts. In addition, it is detected in thymus, spleen, lymph node, brain, liver, kidney, urinary bladder, testis, skin, heart, muscle, bone marrow, alveolar macrophages, peripheral blood neutrophils and the umbilical cord. The only cells evaluated that does not express pBD-1 TFA are peripheral blood mononuclear cells[1].

Molecular Weight

7180.00

Formula

C₃₁₂H₅₄₄F₃N₉₁O₇₅S₁₁

Sequence

{Met}{Arg}{Leu}{His}{Arg}{Leu}{Leu}{Leu}{Val}{Phe}{Leu}{Leu}{Met}{Val}{Leu}{Leu}{Pro}{Val}{Pro}{Gly}{Leu}{Leu}{Lys}{Asn}{Ile}{Gly}{Asn}{Ser}{Val}{Ser}{Cys}{Leu}{Arg}{Asn}{Lys}{Gly}{Val}{Cys}{Met}{Pro}{Gly}{Lys}{Cys}{Ala}{Pro}{Lys}{Met}{Lys}{Gln}{Ile}{Gly}{Thr}{Cys}{Gly}{Met}{Pro}{Gln}{Val}{Lys}{Cys}{Cys}{Lys}{Arg}{Lys}

Sequence Shortening

MRLHRLLLVFLLMVLLPVPGLLKNIGNSVSCLRNKGVCMPGKCAPKMKQIGTCGMPQVKCCKRK

SMILES

[MRLHRLLLVFLLMVLLPVPGLLKNIGNSVSCLRNKGVCMPGKCAPKMKQIGTCGMPQVKCCKRK (TFA salt)]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

pBD-1pBD1pBD 1BacterialAntibioticporcinetissuesxenotransplantationmucosalsystemichostdefensebeta-defensinStaphylococcus aureusInhibitorinhibitorinhibit

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pBD-1 TFA
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HY-P2289A
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