1. GPCR/G Protein
    Neuronal Signaling
  2. Sigma Receptor
  3. Pentoxyverine

Pentoxyverine (Synonyms: Carbetapentane)

Cat. No.: HY-134004
Handling Instructions

Pentoxyverine (Carbetapentane) is a sigma-1 receptor agonist, with a Ki of 75 nM on guinea-pig brain membranes. Pentoxyverine is a centrally-acting cough suppressant with antimuscarinic and anticonvulsant properties. Pentoxyverine can be used for inhibiting bronchial interceptor, weakening of cough reflex, bronchial smooth muscle relaxation and reduction of airway resistance.

For research use only. We do not sell to patients.

Pentoxyverine Chemical Structure

Pentoxyverine Chemical Structure

CAS No. : 77-23-6

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
10 mg USD 50 In-stock
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25 mg USD 90 In-stock
Estimated Time of Arrival: December 31
50 mg USD 140 In-stock
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100 mg USD 200 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Pentoxyverine (Carbetapentane) is a sigma-1 receptor agonist, with a Ki of 75 nM on guinea-pig brain membranes. Pentoxyverine is a centrally-acting cough suppressant with antimuscarinic and anticonvulsant properties. Pentoxyverine can be used for inhibiting bronchial interceptor, weakening of cough reflex, bronchial smooth muscle relaxation and reduction of airway resistance[1][2][3][4].

IC50 & Target

Ki: 75 nM (sigma-1 receptor)[4]

In Vitro

Pentoxyverine competitive binds to [3H]-pentazocine-labelled sites on guinea-pig brain membranes, with a Ki of 75 nM[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Pentoxyverine (1-5 mg/kg; a single i.p.) inhibits citric-acid-induced cough in guinea-pigs[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

333.47

Formula

C₂₀H₃₁NO₃

CAS No.
SMILES

O=C(C1(C2=CC=CC=C2)CCCC1)OCCOCCN(CC)CC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (749.69 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9988 mL 14.9939 mL 29.9877 mL
5 mM 0.5998 mL 2.9988 mL 5.9975 mL
10 mM 0.2999 mL 1.4994 mL 2.9988 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (6.24 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (6.24 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (6.24 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

PentoxyverineCarbetapentaneSigma Receptorsigma-1centrallycoughantimuscarinicanticonvulsantbronchialInhibitorinhibitorinhibit

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Product Name:
Pentoxyverine
Cat. No.:
HY-134004
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