2. GPCR/G Protein
  3. Prostaglandin Receptor Bradykinin Receptor
  4. FR191413

FR191413 is a selective bradykinin B2 receptor agonist that stimulates prostaglandin E2 production in WI-38 cells and activates BK B2 receptor-mediated pathways such as vasodilation and organ protection. FR191413 competitively binds to [3H]-BK in guinea pig ileum (GPI) membranes and CHO cells transfected with the human BK B2 receptor, with IC50 values ​​of 20.0 nM and 2.60 nM, respectively. FR191413 can be used in research related to cardiovascular diseases and diabetes, including hypertension, myocardial hypertrophy, myocardial infarction, arrhythmias, and diabetic nephropathy.

For research use only. We do not sell to patients.

FR191413

FR191413 Chemical Structure

CAS No. : 194928-55-7

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FR191413 Related Antibodies

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Bradykinin B1 Receptor (B1R) Bradykinin B2 Receptor (B2R)

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Description

FR191413 is a selective bradykinin B2 receptor agonist that stimulates prostaglandin E2 production in WI-38 cells and activates BK B2 receptor-mediated pathways such as vasodilation and organ protection. FR191413 competitively binds to [3H]-BK in guinea pig ileum (GPI) membranes and CHO cells transfected with the human BK B2 receptor, with IC50 values ​​of 20.0 nM and 2.60 nM, respectively. FR191413 can be used in research related to cardiovascular diseases and diabetes, including hypertension, myocardial hypertrophy, myocardial infarction, arrhythmias, and diabetic nephropathy[1].

IC50 & Target

Bradykinin B2 Receptor (B2R)

 

EP2

 

In Vitro

FR191413 binds to GPI membranes and human B2 receptor-expressing CHO cells with IC50 values of 20.0 nM and 2.60 nM, respectively, and stimulates prostaglandin E2 production in WI-38 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

FR191413 Related Antibodies
Molecular Weight

688.57

Formula

C34H31Cl2N7O5
CAS No.
SMILES

O(CC1=C(Cl)C(N(C(CNC(/C=C/C=2C=CC(NC(C)=O)=NC2)=O)=O)C)=CC=C1Cl)C3=C4C(N(CC5=CC=CC=N5)C(OC)=N4)=CC=C3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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FR191413 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FR191413194928-55-7FR 191413FR-191413Prostaglandin ReceptorBradykinin ReceptorGPI membraneshuman B? receptor-expressing CHO cellsmyocardial hypertrophyarrhythmiascardiovascular diseasemyocardial infarctionbradykinin B2 receptorbradykinin B2 receptor agonistdiabetic nephropathyWI-38 cellshypertensionprostaglandin E?human modelsInhibitorinhibitorinhibit

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FR191413
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