Trichlorfon ethyl
Trichlorfon ethyl is an analog of Trichlorfon (HY-B1220), as well as an inhibitor of Butyrylcholinesterase and Bacillus subtilis Esterase. Trichlorfon ethyl acts as a prenatal brain growth inhibitor, causing mild reductions in total brain weight, medulla oblongata weight and tectum weight in newborn guinea pigs, without affecting cerebellar weight. Trichlorfon ethyl does not induce severe prenatal brain hypoplasia in guinea pig offspring. Trichlorfon ethyl can be used in studies related to brain hypoplasia.
For research use only. We do not sell to patients.
- CAS No.: 993-86-2
- Formula: C6H12Cl3O4P
- Molecular Weight:285.49
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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BChE |
Trichlorfon ethyl (Compound Ih) (0.1 mM; 1-10 min) inhibits butyrylcholinesterase from horse blood serum with a kII of 2.75×103 L mol-1 min-1 and Bacillus subtilis esterase with a kII of 4.06×102 L mol-1 min-1[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Outbred albino guinea pigs (Ssc:AL, Mol:DHF; pregnant dams)[1]
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Dosage:125 mg/kg (gestational days 44, 45, 46); 138 mg/kg (gestational day 42); 121 mg/kg (gestational day 44)
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Administration:Single dose on specified gestational days
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Result:Showed no significant reductions in total brain weight or weights of cerebellum, medulla oblongata, diencephalon, hippocampus, quadrigemina, or cerebral cortex in offspring exposed to 125 mg/kg, compared to saline controls.
Showed a significant reduction in total brain weight (mean 2.47 g, p < 0.05), medulla oblongata weight (mean 163 mg, p < 0.05), and quadrigemina weight (mean 73 mg, p < 0.05), but no significant reduction in cerebellum weight in offspring exposed to 138 mg/kg (day 42) and 121 mg/kg (day 44).
Reduced red blood cell acetylcholinesterase activity to 51% of control levels 24 hours after administration of 125 mg/kg.
Observed no significant changes in glutamate decarboxylase, choline acetyltransferase, or acetylcholinesterase activities in cerebellum, medulla, or cerebral cortex of offspring exposed to ethyl-trichlorfon.
Chemical Information
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CAS No. 993-86-2
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Molecular Weight 285.49
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Formula C6H12Cl3O4P
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SMILES
ClC(Cl)(C(O)P(OCC)(OCC)=O)Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Trichlorfon ethyl Related Classifications
HY-113737 Related Classifications
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