1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. ICA-069673

ICA-069673 

Cat. No.: HY-101396 Purity: 99.70%
Handling Instructions

ICA-069673 is a KCNQ2/Q3 potassium channel activator with an IC50 of 0.69 μM.

For research use only. We do not sell to patients.

ICA-069673 Chemical Structure

ICA-069673 Chemical Structure

CAS No. : 582323-16-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 92 In-stock
Estimated Time of Arrival: December 31
5 mg USD 84 In-stock
Estimated Time of Arrival: December 31
10 mg USD 144 In-stock
Estimated Time of Arrival: December 31
25 mg USD 312 In-stock
Estimated Time of Arrival: December 31
50 mg USD 552 In-stock
Estimated Time of Arrival: December 31
100 mg USD 984 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

ICA-069673 is a KCNQ2/Q3 potassium channel activator with an IC50 of 0.69 μM.

IC50 & Target

IC50: 0.69 μM (KCNQ2/Q3 potassium channel)[1]

In Vitro

ICA-069673 is found to be 20-fold selective for KCNQ2/Q3 over KCNQ3/Q5 and has no measurable activity against a panel of cardiac ion channels (IC50 values > 30 μM for hERG, Nav1.5, L type channels, and KCNQ1) as well as no activity on GABA(A) gated channels at 10 μM[1]. ICA-069673 exhibits much stronger effects on KCNQ2 channels, including a large hyperpolarizing shift of the voltage-dependence of activation, an 2-fold enhancement of peak current and pronounced subtype specificity for KCNQ2 over KCNQ3. Based on ICA73 sensitivity of chimeric constructs of the transmembrane segments of KCNQ2 and KCNQ3, this drug appears to interact with the KCNQ2 voltage sensor (S1-S4)[2].

Molecular Weight

269.63

Formula

C₁₁H₆ClF₂N₃O

CAS No.

582323-16-8

SMILES

O=C(NC1=CN=C(Cl)N=C1)C2=CC=C(F)C(F)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 34 mg/mL (126.10 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7088 mL 18.5439 mL 37.0879 mL
5 mM 0.7418 mL 3.7088 mL 7.4176 mL
10 mM 0.3709 mL 1.8544 mL 3.7088 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

ICA-069673ICA069673ICA 069673Potassium ChannelKcsAInhibitorinhibitorinhibit

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ICA-069673
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HY-101396
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