582323-16-8
Chemical Structure
ICA-069673
- CAS No.: 582323-16-8
- Formula:C11H6ClF2N3O
- Molecular Weight:269.63
IUPAC Name: N-(2-chloropyrimidin-5-yl)-3,4-difluorobenzamide
InChIKey: IIBSHMFXVWTQSJ-UHFFFAOYSA-N
SMILES: O=C(NC1=CN=C(Cl)N=C1)C2=CC=C(F)C(F)=C2
Biological Activity: ICA-069673 is a KCNQ2/Q3 potassium channel activator. ICA-069673 demonstrates greater selectivity for KV7.2/7.3 over KV7.3/KV7.5, with EC50s of 0.69 μM and 14.3 μM, respectively. ICA-069673 inhibits spontaneous phasic and nerve-evoked contractions in guinea pig detrusor smooth muscle (DSM). ICA-069673 also decreases the global intracellular Ca(2+) concentration in DSM cells[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
ICA-069673 | 99.20% | ICA-069673 is a KCNQ2/Q3 potassium channel activator. ICA-069673 demonstrates greater selectivity for KV7.2/7.3 over KV7.3/KV7.5, with EC50s of 0.69 μM and 14.3 μM, respectively. ICA-069673 inhibits spontaneous phasic and nerve-evoked contractions in guinea pig detrusor smooth muscle (DSM). ICA-069673 also decreases the global intracellular Ca(2+) concentration in DSM cells. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
ICA-069673 (Standard) | ≥98% | ICA-069673 (Standard) is the analytical standard of ICA-069673 (HY-101396). This product is intended for research and analytical applications. ICA-069673 is a KCNQ2/Q3 potassium channel activator. ICA-069673 demonstrates greater selectivity for KV7.2/7.3 over KV7.3/KV7.5, with EC50s of 0.69 μM and 14.3 μM, respectively. ICA-069673 inhibits spontaneous phasic and nerve-evoked contractions in guinea pig detrusor smooth muscle (DSM). ICA-069673 also decreases the global intracellular Ca(2+) concentration in DSM cells. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Keywords
