L 689660 maleate
L 689660 maleate, a cholinomimetic agent, is a selective M1 and M3 muscarinic receptors agonist. L 689660 maleate is a potent M1 muscarinic receptor full agonist in the rat superior cervical ganglion (pEC50 of 7.3). L 689660 maleate is a potent M3 receptors agonist in the guinea-pig ileum myenteric plexus-longitudinal muscle or in trachea (pEC50 of 7.5 and 7.7, respectively).
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- CAS No.: 144860-79-7
- Formula: C15H18ClN3O4
- Molecular Weight:339.77
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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mAChR1 |
mAChR3 |
Chemical Information
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CAS No. 144860-79-7
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Molecular Weight 339.77
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Formula C15H18ClN3O4
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SMILES
ClC1=CN=CC(C2CN3CCC2CC3)=N1.O=C(/C=C\C(O)=O)O.[x]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Hargreaves RJ, et al. L-689,660, a novel cholinomimetic with functional selectivity for M1 and M3 muscarinic receptors. Br J Pharmacol. 1992 Oct;107(2):494-501. [Content Brief]
[2]. Aagaard P, et al. Pharmacological characterization of the novel cholinomimetic L-689,660 at cloned and native brain muscarinic receptors. J Pharmacol Exp Ther. 1993 Dec;267(3):1478-83. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
L 689660 maleate Related Classifications
HY-120915 Related Classifications
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