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Cat. No.: HY-182515

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U-19052

U-19052 is a selective competitive peptidoleukotriene D/E receptor antagonist. U-19052 acts as a reversible antagonist that not affecting responses to non-leukotriene agonists. U-19052 does not exhibit agonist activity or induce contraction in guinea pig tracheal or ileal strips. U-19052 is a leukotriene antagonist developed by modifying leukotriene chemical structure. U-19052 can be used for the research of allergic asthma and hypersensitivity diseases.

For research use only. We do not sell to patients.

CAS No.: 112682-32-3
Formula: C₃₁H₄₂O₆S
Molecular Weight:542.73

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

U-19052 Chemical Structure

CAS No.: 112682-32-3

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

All Leukotriene Receptor Isoforms :

In Vitro

U-19052 (10 μM; 30 min) acts as a selective, competitive antagonist of peptidoleukotriene receptors on guinea pig tracheal strips, with a pK_B of 6.43 against LTD₄, 5.80 against LTE₄, and 5.54 against LTC₄^[1].
U-19052 (10 μM; 10 min) inhibits LTE₄-induced contraction of guinea pig tracheal strips without exhibiting agonist activity^[1].
U-19052 (10 μM; 60 min) acts as a competitive antagonist of peptidoleukotriene receptors on guinea pig ileal segments, with a pK_B of 7.25 against LTD₄ and 7.17 against LTE₄^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 112682-32-3
Molecular Weight 542.73
Formula C₃₁H₄₂O₆S
SMILES

CCCCCCCC(C=C1)=CC=C1C/C=C\[C@H]([C@@H](O)CCCC(O)=O)SCC2=C(C=C(C=C2)C(O)=O)OC
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Bernstein PR, et al. Synthesis and pharmacological characterization of a series of leukotriene analogues with antagonist and agonist activities. J Med Chem. 1988 Mar;31(3):692-6. [Content Brief]

[2]. Terada H, et al. Structural requirements of leukotriene antagonists. Pharmacochem. Libr. 1995; 23:341-367.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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