112682-32-3
Chemical Structure
U-19052
- CAS No.: 112682-32-3
- Formula:C31H42O6S
- Molecular Weight:542.73
InChIKey: FDJAQZAHMLOHQY-CPEABZCDSA-N
SMILES: CCCCCCCC(C=C1)=CC=C1C/C=C\[C@H]([C@@H](O)CCCC(O)=O)SCC2=C(C=C(C=C2)C(O)=O)OC
Biological Activity: U-19052 is a selective competitive peptidoleukotriene D/E receptor antagonist. U-19052 acts as a reversible antagonist that not affecting responses to non-leukotriene agonists. U-19052 does not exhibit agonist activity or induce contraction in guinea pig tracheal or ileal strips. U-19052 is a leukotriene antagonist developed by modifying leukotriene chemical structure. U-19052 can be used for the research of allergic asthma and hypersensitivity diseases[1][2].
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U-19052 | U-19052 is a selective competitive peptidoleukotriene D/E receptor antagonist. U-19052 acts as a reversible antagonist that not affecting responses to non-leukotriene agonists. U-19052 does not exhibit agonist activity or induce contraction in guinea pig tracheal or ileal strips. U-19052 is a leukotriene antagonist developed by modifying leukotriene chemical structure. U-19052 can be used for the research of allergic asthma and hypersensitivity diseases. | |||||||||||||||||||||
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References
- [1]. Bernstein PR, et al. Synthesis and pharmacological characterization of a series of leukotriene analogues with antagonist and agonist activities. J Med Chem. 1988 Mar;31(3):692-6. [Content Brief]
- [2]. Terada H, et al. Structural requirements of leukotriene antagonists. Pharmacochem. Libr. 1995; 23:341-367.
