1. GPCR/G Protein
  2. Endothelin Receptor
  3. Sarafotoxin S6a

Sarafotoxin S6a 

Cat. No.: HY-P1112
Handling Instructions

Sarafotoxin S6a, a sarafotoxin analogue, is a endothelin receptor agonist and has an ETA/ETB selectivity profile similar to that of Endothelin-3 (HY-P0204). Sarafotoxin S6a elicits the pig coronary artery with an EC50 value of 7.5 nM.

For research use only. We do not sell to patients.

Sarafotoxin S6a Chemical Structure

Sarafotoxin S6a Chemical Structure

CAS No. : 126738-34-9

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Description

Sarafotoxin S6a, a sarafotoxin analogue, is a endothelin receptor agonist and has an ETA/ETB selectivity profile similar to that of Endothelin-3 (HY-P0204). Sarafotoxin S6a elicits the pig coronary artery with an EC50 value of 7.5 nM[1].

IC50 & Target[1]

ETB

 

ETA

 

In Vitro

Sarafotoxin S6a is a rather weak agonist effect in guinea-pig aorta, the eliting concentration (EC50) is 150 nM in guinea-pig aorta[1].

Molecular Weight

2514.85

Formula

C₁₀₅H₁₅₆N₂₈O₃₄S₅

CAS No.

126738-34-9

Sequence

Cys-Ser-Cys-Lys-Asp-Met-Thr-Asp-Lys-Glu-Cys-Leu-Asn-Phe-Cys-His-Gln-Asp-Val-Ile-Trp (Disulfide bridge:Cys1-Cys15;Cys3-Cys11)

Sequence Shortening

CSCKDMTDKECLNFCHQDVIW (Disulfide bridge:Cys1-Cys15;Cys3-Cys11)

SMILES

[CSCKDMTDKECLNFCHQDVIW (Disulfide bridge:Cys1-Cys15;Cys3-Cys11)]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vivo:
  • 1.

    S6a is dissolved in 0.1% aqueous acetic acid and diluted in 0.9% NaCl[1].

References
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Keywords:

Sarafotoxin S6aEndothelin Receptorguinea-pigaortaendothelin receptorcoronary arteryEndothelin-3Inhibitorinhibitorinhibit

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Sarafotoxin S6a
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HY-P1112
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