1. GPCR/G Protein
    Neuronal Signaling
    Immunology/Inflammation
  2. Histamine Receptor
    mGluR
  3. Oxomemazine

Oxomemazine 

Cat. No.: HY-136587
Handling Instructions

Oxomemazine is a phenothiazine-based histamine H1-receptor blocker with pronounced antimuscarinic properties. Oxomemazine is a selective antagonist for muscarinic M1 receptor, displays about 20-fold difference in the affinity for high (Ki = 84 nM, M1 receptor) and low (Ki = 1.65 μM, M2 receptor) affinity sites. Oxomemazine an antihistamine and anticholinergic agent used for the study of cough treatment.

For research use only. We do not sell to patients.

Oxomemazine Chemical Structure

Oxomemazine Chemical Structure

CAS No. : 3689-50-7

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Description

Oxomemazine is a phenothiazine-based histamine H1-receptor blocker with pronounced antimuscarinic properties. Oxomemazine is a selective antagonist for muscarinic M1 receptor, displays about 20-fold difference in the affinity for high (Ki = 84 nM, M1 receptor) and low (Ki = 1.65 μM, M2 receptor) affinity sites[1]. Oxomemazine an antihistamine and anticholinergic agent used for the study of cough treatment[2].

IC50 & Target[1][2]

H1 Receptor

 

mGluR 1

84 nM (Ki)

mGluR2

1.65 μM (Ki)

Molecular Weight

330.44

Formula

C₁₈H₂₂N₂O₂S

CAS No.

3689-50-7

SMILES

CC(CN1C2=C(C=CC=C2)S(C3=CC=CC=C13)(=O)=O)CN(C)C

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

OxomemazineHistamine ReceptormGluRMetabotropic glutamate receptorsphenothiazinehistamine H1-receptorantimuscarinicmuscarinic M1antihistamineanticholinergiccoughInhibitorinhibitorinhibit

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Oxomemazine
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HY-136587
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