THE EFFECT OF SOME NEW ANTIHISTAMINES ON THE ANAPHYLACTIC MICROSHOCK OF THE GUINEA-PIG

  • Br J Pharmacol Chemother. 1963 Dec;21(3):414-8. doi: 10.1111/j.1476-5381.1963.tb02008.x.
H HERXHEIMER ,  E STRESEMANN
PMID: 14110740 DOI: 10.1111/j.1476-5381.1963.tb02008.x
Abstract

The dose/response curves for the protective effects of the new antihistamine compounds trimeprazine, 10-(3-diethylamino-2-methylpropyl)phenothiazine 1,1-dioxide hydrochloride (oxomemazine hydrochloride), cyproheptadine, homochlorcyclizine and methotrimeprazine against the anaphylactic microshock of the guinea-pig were similar to that of promethazine. The first three compounds, however, protected at lower doses than promethazine (5 to 10 mug/kg). The protective effect of cyproheptadine lasted longer than 24 hr.

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