GW 833972A 

GW 833972A is a selective CB₂ receptor agonist with pEC₅₀ of the human CB₂ receptor for GW 833972A of 7.3, and its selectivity for the CB₂ receptor is approximately 1000 times higher than that for the CB₁ receptor. GW 833972A inhibits induced neuronal depolarization and suppresses coughing caused by citric acid in guinea pig models. GW 833972A can be used for the study of chronic cough^[1].

GW 833972A (0.3-300 μM; 10 min) inhibits capsaicin-induced depolarization in humans and guinea pigs, and also inhibits prostaglandin E(2) and hypertonic saline induced depolarization of isolated vagus nerve in guinea pigs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GW 833972A (30 mg/kg, 2 mL/kg; i.p.; single dose 30 min before test) inhibits tussive response in conscious guinea pigs induced by citric acid. It also inhibits capsaicin-induced plasma protein exudation in the main bronchus^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

444.24

C₁₈H₁₄Cl₂F₃N₅O

1092502-33-4

Solid

White to off-white

O=C(C1=CN=C(NC2=CC=CC(Cl)=C2)N=C1C(F)(F)F)NCC3=CC=NC=C3.[H]Cl

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Belvisi MG, et al. Inhibitory activity of the novel CB2 receptor agonist, GW833972A, on guinea-pig and human sensory nerve function in the airways. Br J Pharmacol. 2008 Oct;155(4):547-57.  [Content Brief]