Manoalogue 

Manoalogue is an irreversible secretory phospholipase A2 (sPLA2) inhibitor. Manoalogue covalently modifies K94 of bee venom phospholipase A2 (bvPLA2) to inactivate the enzyme and shows selective inhibition on bvPLA2. Manoalogue can suppress PLA2-mediated contractions of guinea pig lung pleural strips. Manoalogue is used for sPLA2 mechanism and respiratory physiology research^[1][2].

Manoalogue (manoalogue/bvPLA2 mole ratio of 20; 20-120 min) inactivates wild-type bvPLA2 and most lysine-to-glutamate bvPLA2 mutants by covalent modification of lysine 94 (K94), while the K94E mutant is fully resistant to this inactivation, and the K85E mutant shows slight resistance^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Manoalogue (24 hr pre-incubation) markedly suppresses PLA2-induced contractions of guinea pig lung pleural strips^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

318.41

C₁₉H₂₆O₄

136440-42-1

C/C(C)=C/CC/C(C)=C/C/C(C=O)=C\CCC(C(O1)O)=CC1=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Snyder DW, et al. Evidence that phospholipase A2 (PLA2) inhibitors can selectively block PLA2-mediated contractions of guinea pig lung pleural strips. J Pharmacol Exp Ther. 1992;262(3):1147-1153.

  [2]. Ghomashchi F, et al. Interfacial recognition by bee venom phospholipase A2: insights into nonelectrostatic molecular determinants by charge reversal mutagenesis. Biochemistry. 1998;37(19):6697-6710.