2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. Alosetron (Hydrochloride(1:X))

Alosetron (Hydrochloride(1:X))  (Synonyms: GR 68755 (Hydrochloride(1:X)); GR 68755X (Hydrochloride(1:X)))

Cat. No.: HY-70050
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Alosetron (GR 68755) Hydrochloride(1:X) is a potent and highly selective serotonin 5-HT3 receptor antagonist. Alosetron Hydrochloride(1:X) is used for the research of irritable bowel syndrome (IBS). Alosetron Hydrochloride(1:X) blocks the fast 5HT3-mediated depolarisation of guinea-pig myenteric and submucosal neurons, with IC50 at ~55 nM. Alosetron Hydrochloride(1:X) attenuates the visceral nociceptive effect of rectal distension in conscious or anaesthetised dogs. Anti-inflammatory effects.

For research use only. We do not sell to patients.

Alosetron (Hydrochloride(1:X)) Chemical Structure

Alosetron (Hydrochloride(1:X)) Chemical Structure

CAS No. : 132414-02-9

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Alosetron (Hydrochloride(1:X)) Related Antibodies

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Description

Alosetron (GR 68755) Hydrochloride(1:X) is a potent and highly selective serotonin 5-HT3 receptor antagonist. Alosetron Hydrochloride(1:X) is used for the research of irritable bowel syndrome (IBS). Alosetron Hydrochloride(1:X) blocks the fast 5HT3-mediated depolarisation of guinea-pig myenteric and submucosal neurons, with IC50 at ~55 nM. Alosetron Hydrochloride(1:X) attenuates the visceral nociceptive effect of rectal distension in conscious or anaesthetised dogs. Anti-inflammatory effects[1][2].

IC50 & Target

5-HT3 Receptor

 

In Vivo

Dexamethasone and Alosetron-treated (1 mg/kg; ip; daily for 6 days) rats exhibits a significant decrease in the diarrhea index, in comparison with TNBS-control group, especially after the initial 2 days of treatment following the induction of colitis[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Formula

C17H18N4O.xClH
CAS No.
SMILES

O=C1N(CC2=C(NC=N2)C)CCC(N3C)=C1C4=C3C=CC=C4.[x HCl]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Alosetron (Hydrochloride(1:X)) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Alosetron (Hydrochloride(1:X))132414-02-9GR 68755 (Hydrochloride(1:X)) GR 68755X (Hydrochloride(1:X))5-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorselectivedepolarizationvisceralnociceptivecolitisInhibitorinhibitorinhibit

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