CP-288886
CP-288886 is a cysLT1 receptor antagonist with a Ki value of 0.004 μM. CP-288886 exhibits comparable activity to Zafirlukast (HY-17492) and Pranlukast (HY-B0290). CP-288886 inhibits calcium mobilization with an IC50 of 0.0005 μM in human U937 cells. CP-288886 has high oral bioavailability. CP-288886 possesses anti-asthmatic activity in a guinea pig asthma model and can be used for the research of diseases such as asthma.
For research use only. We do not sell to patients.
- CAS No.: 221332-74-7
- Formula: C30H28ClF3N2O6S
- Molecular Weight:637.07
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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CysLT1 0.004 μM (Ki) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| U-937 | IC50 |
0.0005 μM
Compound: 7
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Compound was tested for its ability to inhibit calcium influx in human U937 cells
Compound was tested for its ability to inhibit calcium influx in human U937 cells
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[PMID: 9934474] |
Chemical Information
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CAS No. 221332-74-7
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Molecular Weight 637.07
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Formula C30H28ClF3N2O6S
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SMILES
O[C@H]1C2=CC(OCC3=NC4=CC(Cl)=CC=C4C=C3)=CC=C2OC(C)(C)[C@H]1CC5=C(C=CC(NS(C(F)(F)F)(=O)=O)=C5)OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CP-288886 Related Classifications
HY-105358 Related Classifications
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