2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. (-)-Eseroline fumarate

(-)-Eseroline fumarate  (Synonyms: Eseroline fumarate)

Cat. No.: HY-129101 Purity: 98.03%
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(-)-Eseroline fumarate is a metabolic of Physostigmine (HY-N6608), an AChE inhibitor. (-)-Eseroline fumarate elicits a leakage of lactic acid dehydrogenase (LDH) from cancer cells. (-)-Eseroline fumarate also induces the release of adenine nucleotides and 5-hydroxytryptamine (5-HT) from neuronal cells, thus induce cell death. (-)-Eseroline fumarate inhibits the electrically evoked twitches of the mouse vas deferens and of the guinea-pig ileum.

For research use only. We do not sell to patients.

(-)-Eseroline fumarate

(-)-Eseroline fumarate Chemical Structure

CAS No. : 70310-73-5

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Based on 1 publication(s) in Google Scholar

Other Forms of (-)-Eseroline fumarate:

(-)-Eseroline fumarate Related Antibodies

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Description

(-)-Eseroline fumarate is a metabolic of Physostigmine (HY-N6608), an AChE inhibitor. (-)-Eseroline fumarate elicits a leakage of lactic acid dehydrogenase (LDH) from cancer cells. (-)-Eseroline fumarate also induces the release of adenine nucleotides and 5-hydroxytryptamine (5-HT) from neuronal cells, thus induce cell death. (-)-Eseroline fumarate inhibits the electrically evoked twitches of the mouse vas deferens and of the guinea-pig ileum[1][2].

In Vitro

(-)-Eseroline fumarate (0.5 mM; 0-25 hr) time-dependently induces LDH leakage of neuronal cell culture systems: mouse neuroblastoma N1E-115, rat glioma C6, and neuroblastoma-glioma hybrid NG 108-15[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(-)-Eseroline fumarate Related Antibodies
In Vivo

(-)-Eseroline fumarate (HCl; 10 mg/kg; i.v.; single dose) induces the release of 5-HT from cerebral cortex in adult mongrel cats[2].
(-)-Eseroline fumarate (salicylate; 9 mg/kg; s.c.; single dose) shows analgesic effect and strongly reduces antinociceptive effect of Physostigmine (HY-N6608) in the mouse tail-flick test[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

334.37

Formula

C17H22N2O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC(/C=C/C(O)=O)=O.C[C@]12C3=CC(O)=CC=C3N([C@@]1([H])N(CC2)C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

0.1 M HCl : 50 mg/mL (149.53 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9907 mL 14.9535 mL 29.9070 mL
5 mM 0.5981 mL 2.9907 mL 5.9814 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
0.1 M HCl 1 mM 2.9907 mL 14.9535 mL 29.9070 mL 74.7675 mL
5 mM 0.5981 mL 2.9907 mL 5.9814 mL 14.9535 mL
10 mM 0.2991 mL 1.4953 mL 2.9907 mL 7.4767 mL
15 mM 0.1994 mL 0.9969 mL 1.9938 mL 4.9845 mL
20 mM 0.1495 mL 0.7477 mL 1.4953 mL 3.7384 mL
25 mM 0.1196 mL 0.5981 mL 1.1963 mL 2.9907 mL
30 mM 0.0997 mL 0.4984 mL 0.9969 mL 2.4922 mL
40 mM 0.0748 mL 0.3738 mL 0.7477 mL 1.8692 mL
50 mM 0.0598 mL 0.2991 mL 0.5981 mL 1.4953 mL
60 mM 0.0498 mL 0.2492 mL 0.4984 mL 1.2461 mL
80 mM 0.0374 mL 0.1869 mL 0.3738 mL 0.9346 mL
100 mM 0.0299 mL 0.1495 mL 0.2991 mL 0.7477 mL
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(-)-Eseroline fumarate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(-)-Eseroline70310-73-5Eseroline5-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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