2. GPCR/G Protein Neuronal Signaling Metabolic Enzyme/Protease Membrane Transporter/Ion Channel
  3. Opioid Receptor Cholinesterase (ChE) Drug Metabolite nAChR
  4. Eseroline

Eseroline is a potent μ-opioid receptor agonist, which is the hydrolytic metabolite of Physostigmine (HY-N6608). Eseroline is a selective and competitive acetylcholinesterase (AChE) inhibitor, with its Ki values for AChE and BuChE being 0.1 μM and 200 μM respectively. Eseroline has nicotinic acetylcholine receptor allosteric enhancing ligand (nAChR-APL) activity, meaning it does not activate the receptor but significantly enhances the signal transduction of Ach triggered by the receptor. Eseroline is neurotoxic, causing cell membrane damage (LDH leakage) and energy metabolism collapse (ATP depletion). Eseroline can be used for the study of Alzheimer's disease.

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Eseroline

Eseroline Chemical Structure

CAS No. : 469-22-7

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Eseroline Related Antibodies

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μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

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AChE BChE

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Description

Eseroline is a potent μ-opioid receptor agonist, which is the hydrolytic metabolite of Physostigmine (HY-N6608). Eseroline is a selective and competitive acetylcholinesterase (AChE) inhibitor, with its Ki values for AChE and BuChE being 0.1 μM and 200 μM respectively. Eseroline has nicotinic acetylcholine receptor allosteric enhancing ligand (nAChR-APL) activity, meaning it does not activate the receptor but significantly enhances the signal transduction of Ach triggered by the receptor. Eseroline is neurotoxic, causing cell membrane damage (LDH leakage) and energy metabolism collapse (ATP depletion). Eseroline can be used for the study of Alzheimer's disease[1][2][3].

IC50 & Target[1]

μ Opioid Receptor/MOR

 

AChE

0.1 μM (IC50)

Molecular Weight

218.29

Formula

C13H18N2O
CAS No.
SMILES

C[C@]12C3=CC(O)=CC=C3N([C@@]1([H])N(CC2)C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Eseroline Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Eseroline469-22-7Opioid ReceptorCholinesterase (ChE)Drug MetabolitenAChRNicotinic acetylcholine receptorsAcetylcholinesteraseAlzheimer's Diseasegalantaminemorphinannicotinic acetylcholine receptoropioidrepurposingallosteric potentiating ligand (APL)Inhibitorinhibitorinhibit

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