1. Membrane Transporter/Ion Channel
  2. P2X Receptor
    Na+/Ca2+ Exchanger
  3. PPADS tetrasodium

PPADS tetrasodium 

Cat. No.: HY-101044 Purity: >95.0%
Handling Instructions

PPADS tetrasodiuma is a non-selective P2X receptor antagonist. PPADS tetrasodiuma blocks recombinant P2X1, -2, -3, -5 with IC50s ranging from 1 to 2.6 μM. PPADS tetrasodiuma blocks native P2Y2-like (IC50~0.9 mM) and recombinant P2Y4 (IC50~15 mM) receptors. PPADS tetrasodiuma is an inhibitor of the reverse mode of the Na/Ca²⁺exchanger in guinea pig airway smooth muscle.

For research use only. We do not sell to patients.

PPADS tetrasodium Chemical Structure

PPADS tetrasodium Chemical Structure

CAS No. : 192575-19-2

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10 mM * 1 mL in DMSO USD 521 In-stock
Estimated Time of Arrival: December 31
1 mg USD 285 In-stock
Estimated Time of Arrival: December 31
5 mg USD 395 In-stock
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10 mg USD 670 In-stock
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Description

PPADS tetrasodiuma is a non-selective P2X receptor antagonist. PPADS tetrasodiuma blocks recombinant P2X1, -2, -3, -5 with IC50s ranging from 1 to 2.6 μM. PPADS tetrasodiuma blocks native P2Y2-like (IC50~0.9 mM) and recombinant P2Y4 (IC50~15 mM) receptors. PPADS tetrasodiuma is an inhibitor of the reverse mode of the Na/Ca²⁺exchanger in guinea pig airway smooth muscle[1][2].

In Vitro

PPADS tetrasodiuma (1-30 μM; 10-50 minutes) inhibits Na+/Ca2+ exchanger reverse mode (NCXREV) in a time- and concentration dependent manner[2].
PPADS tetrasodiuma is effective at other native and recombinant P2XRs. At human P2XRs sensitivity to PPADS tetrasodiuma depended on the subtype and was highest at the hP2X1, -2, -3, -5, and -7Rs with an IC50 of ∼1–3 and ∼30 μM for the hP2X4R[3].

In Vivo

PPADS tetrasodiuma (15-60 mg/100g body weight (BW); i.p.; every 12 hours for 8 days) inhibits glomerular mesangial cells (MC) proliferation without altering proliferation of non-MC in vivo in mesangial proliferative glomerulonephritis[4].

Animal Model: Male Sprague-Dawley ratsweighing 160 to 200 g (anti-Thy1 disease mode)[4]
Dosage: 15 mg/100g BW, 30 mg/100g BW, 60 mg/100g BW
Administration: i.p.; every 12 hours for 8 days (the first PPADS injection was administered 60 minutes after disease induction, and the loading dose always contained double the amount of PPADS compared to the following injections.)
Result: Specifically and dose-dependently reduced early (day 3) glomerular mesangial cell proliferation without altering proliferation of non-MC.
Molecular Weight

599.30

Formula

C₁₄H₁₀N₃Na₄O₁₂PS₂

CAS No.

192575-19-2

SMILES

O=S(C1=CC=C(/N=N/C2=NC(C)=C(O)C(C=O)=C2COP([O-])([O-])=O)C(S(=O)([O-])=O)=C1)([O-])=O.[Na+].[Na+].[Na+].[Na+]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >95.0%

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Keywords:

PPADS tetrasodiumP2X ReceptorNa+/Ca2+ ExchangerP2XRsguineapigairwaysmoothmuscleexchangerglomerularmesangialcellATP-sensitiveproliferationInhibitorinhibitorinhibit

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PPADS tetrasodium
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