1. Membrane Transporter/Ion Channel
  2. P2X Receptor Na+/Ca2+ Exchanger
  3. PPADS tetrasodium

PPADS tetrasodium 

Cat. No.: HY-101044 Purity: ≥95.0%
COA Handling Instructions

PPADS tetrasodiuma is a non-selective P2X receptor antagonist. PPADS tetrasodiuma blocks recombinant P2X1, -2, -3, -5 with IC50s ranging from 1 to 2.6 μM. PPADS tetrasodiuma blocks native P2Y2-like (IC50~0.9 mM) and recombinant P2Y4 (IC50~15 mM) receptors. PPADS tetrasodiuma is an inhibitor of the reverse mode of the Na/Ca2+ exchanger in guinea pig airway smooth muscle.

For research use only. We do not sell to patients.

PPADS tetrasodium Chemical Structure

PPADS tetrasodium Chemical Structure

CAS No. : 192575-19-2

Size Price Stock Quantity
Solution
10 mM * 1 mL in Water USD 198 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 198 In-stock
Solid
1 mg USD 60 In-stock
5 mg USD 150 In-stock
10 mg USD 230 In-stock
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Based on 1 publication(s) in Google Scholar

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1 Publications Citing Use of MCE PPADS tetrasodium

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

PPADS tetrasodiuma is a non-selective P2X receptor antagonist. PPADS tetrasodiuma blocks recombinant P2X1, -2, -3, -5 with IC50s ranging from 1 to 2.6 μM. PPADS tetrasodiuma blocks native P2Y2-like (IC50~0.9 mM) and recombinant P2Y4 (IC50~15 mM) receptors. PPADS tetrasodiuma is an inhibitor of the reverse mode of the Na/Ca2+ exchanger in guinea pig airway smooth muscle[1][2].

In Vitro

PPADS tetrasodiuma (1-30 μM; 10-50 minutes) inhibits Na+/Ca2+ exchanger reverse mode (NCXREV) in a time- and concentration dependent manner[2].
PPADS tetrasodiuma is effective at other native and recombinant P2XRs. At human P2XRs sensitivity to PPADS tetrasodiuma depended on the subtype and is highest at the hP2X1, -2, -3, -5, and -7Rs with an IC50 of ~1-3 and ~30 μM for the hP2X4R[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

PPADS tetrasodiuma (15-60 mg/100g body weight (BW); i.p.; every 12 hours for 8 days) inhibits glomerular mesangial cells (MC) proliferation without altering proliferation of non-MC in vivo in mesangial proliferative glomerulonephritis[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley ratsweighing 160 to 200 g (anti-Thy1 disease mode)[4]
Dosage: 15 mg/100g BW, 30 mg/100g BW, 60 mg/100g BW
Administration: i.p.; every 12 hours for 8 days (the first PPADS injection was administered 60 minutes after disease induction, and the loading dose always contained double the amount of PPADS compared to the following injections.)
Result: Specifically and dose-dependently reduced early (day 3) glomerular mesangial cell proliferation without altering proliferation of non-MC.
Molecular Weight

599.30

Appearance

Solid

Formula

C14H10N3Na4O12PS2

CAS No.
SMILES

O=S(C1=CC=C(/N=N/C2=NC(C)=C(O)C(C=O)=C2COP(O[Na])(O[Na])=O)C(S(=O)(O[Na])=O)=C1)(O[Na])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (83.43 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6686 mL 8.3431 mL 16.6861 mL
5 mM 0.3337 mL 1.6686 mL 3.3372 mL
10 mM 0.1669 mL 0.8343 mL 1.6686 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation

Purity: ≥95.0%

References
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PPADS tetrasodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
PPADS tetrasodium
Cat. No.:
HY-101044
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