2. GPCR/G Protein
  3. Leukotriene Receptor
  4. LY 163443

LY 163443 is a selective antagonist of leukotrienes D4 (LTD4) and E4 (LTE4). LY 163443 can antagonize LTD4-induced contractions of guinea pig ileum, trachea, and lung parenchyma. LY 163443 also inhibits tracheal contractions to LTE4.

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LY 163443 Chemical Structure

LY 163443 Chemical Structure

CAS No. : 97581-70-9

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Description

LY 163443 is a selective antagonist of leukotrienes D4 (LTD4) and E4 (LTE4). LY 163443 can antagonize LTD4-induced contractions of guinea pig ileum, trachea, and lung parenchyma. LY 163443 also inhibits tracheal contractions to LTE4[1][2].

Molecular Weight

366.41

Formula

C20H22N4O3
CAS No.
SMILES

CC(C1=CC=C(C(CCC)=C1O)COC2=CC=C(C=C2)CC3=NN=NN3)=O
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Purity & Documentation
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LY 163443 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LY 16344397581-70-9LY163443LY-163443Leukotriene ReceptorLTD4LTE4ileumtracheaparenchymatracheal contractionInhibitorinhibitorinhibit

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