97581-70-9
97581-70-9
Chemical Structure
LY 163443
- CAS No.: 97581-70-9
- Formula:C20H22N4O3
- Molecular Weight:366.41
IUPAC Name: 1-(4-((4-((1H-tetrazol-5-yl)methyl)phenoxy)methyl)-2-hydroxy-3-propylphenyl)ethan-1-one
InChIKey: OKLGLROKXFUYEI-UHFFFAOYSA-N
SMILES: CC(C1=CC=C(C(CCC)=C1O)COC2=CC=C(C=C2)CC3=NN=NN3)=O
Biological Activity: LY 163443 is a selective antagonist of leukotrienes D4 (LTD4) and E4 (LTE4). LY 163443 can antagonize LTD4-induced contractions of guinea pig ileum, trachea, and lung parenchyma. LY 163443 also inhibits tracheal contractions to LTE4[1][2].
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LY 163443 | LY 163443 is a selective antagonist of leukotrienes D4 (LTD4) and E4 (LTE4). LY 163443 can antagonize LTD4-induced contractions of guinea pig ileum, trachea, and lung parenchyma. LY 163443 also inhibits tracheal contractions to LTE4. | |||||||||||||||||||||
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References
- [1]. Fleisch JH, et, al. Evaluation of LY163443, 1-[2-hydroxy-3-propyl-4-([4- (1H-tetrazol-5-ylmethyl)phenoxy]methyl) phenyl]ethanone, as a pharmacologic antagonist of leukotrienes D4 and E4. Naunyn Schmiedebergs Arch Pharmacol. 1986 May;333(1):70-7. [Content Brief]
- [2]. Bitterman H, et, al. Use of a novel peptide leukotriene receptor antagonist, Ly-163443, in splanchnic artery occlusion shock. Prostaglandins Leukot Essent Fatty Acids. 1988 May;32(2):63-70. [Content Brief]
