Ethisterone  (Synonyms: Pregneninolone; 17α-Ethynyltestosterone)

Ethisterone (Pregneninolone; 17α-Ethynyltestosterone) is a synthetic steroidal estrogen, is an orally active steroidal contraceptive agent. Ethisterone has almost no effect on the phagocytic activity of the reticuloendothelial system in male guinea pigs, while in utero exposure can induce abnormalities in the urogenital system of offspring^[1][2].

Ethisterone acts as an inducer of urogenital abnormalities, with in utero exposure linked to increased offspring urogenital abnormality prevalence, higher risk with earlier exposure onset^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ethisterone (0.5 mg; i.m.; daily; 2-4 weeks) has little or no effect on the phagocytic activity of the reticulo-endothelial system in male guinea pigs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

312.45

C₂₁H₂₈O₂

434-03-7

Solid

Light yellow to yellow

C[C@@]1([C@]2(O)C#C)[C@](CC2)([H])[C@@](CCC3=CC4=O)([H])[C@]([C@]3(CC4)C)([H])CC1

Room temperature in continental US; may vary elsewhere.

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

• [1]. Nicol T, et al. Effect of Ethisterone, β-Œstradiol and Progesterone on the Phagocytic Activity of the Reticulo-Endothelial System[J]. Nature, 1957, 179(4553): 261-261.

  [2]. Beral V, et al. Randomised trial of high doses of stilboestrol and ethisterone therapy in pregnancy: long-term follow-up of the children. J Epidemiol Community Health. 1981;35(3):155-160.