Furazolium hydrochloride
Furazolium hydrochloride is a broad-spectrum antibacterial agent with inhibitory activity against a variety of Gram-positive and Gram-negative Bacterial strains. In a gelatin-acacia complex coacervate system, Furazolium hydrochloride exhibits protein-binding properties, where protein binding dominates at low concentrations, while micellization occurs at high concentrations. Furazolium hydrochloride does not alter the water permeability of cellulose membranes, and it can induce delayed-type hypersensitivity reactions in guinea pigs, with cross-reactivity observed in animals sensitized with aflatoxin B1. Furazolium hydrochloride can be used in studies related to bacterial infections and local wound infections.
For research use only. We do not sell to patients.
- CAS No.: 5118-17-2
- Formula: C9H8ClN3O3S
- Molecular Weight:273.70
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Furazolium hydrochloride (0.116-0.231% ointment; 20 μg/0.1 cc aqueous preparation) does not alter the water permeability of Ethicon Ox cargile membrane[1].
Furazolium hydrochloride (24 h) exhibits broad-spectrum in vitro antibacterial activity, with the strongest activity against E. coli Es-2 and S. typhosa SaD-13 at an MIC of < 0.75 μg/mL; the MIC values against E. insidiosa Er-4, A. aerogenes Ae-6 and S. aureus Sa-1 are 1.5, 3.1 and 6.25 μg/mL, respectively, while the MIC against P. aeruginosa Ps-10, P. vulgaris Pr-12 and S. agalactiae StB-12 is 25 μg/mL[2].
Furazolium hydrochloride exhibits a protein binding rate of 13.9% in the gelatin-acacia complex coacervate system (when the partition coefficient stabilizes at 2.28). Protein binding dominates when the total drug concentration is below 480 μg, while micellization occurs when the concentration exceeds 480 μg[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Hartley albino male guinea pigs, 300-400 g, were sensitized via a single intradermal injection of 25 μg of the test compound in the nuchal region, with 100 μg of Freund's complete adjuvant administered in the foot pads.[3]
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Dosage:25 μg (induction);0.1-20 μg (challenge)
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Administration:i.d.; single dose (induction); i.d. (challenge)
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Result:Showed positive skin reactions in 9/9 sensitized animals at 24 hours with an average intensity of 3.89 and an average area times average intensity of 198.
Showed positive skin reactions in 2/9 sensitized animals at 48 hours with an average intensity of 1.78 and an average area times average intensity of 162.
Induced cross-reactivity in 16/20 guinea pigs strongly sensitized to aflatoxin B1 at 24 hours and 15/20 at 48 hours.
Chemical Information
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CAS No. 5118-17-2
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Molecular Weight 273.70
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Formula C9H8ClN3O3S
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SMILES
O=[N+]([O-])C1=CC=C(C2=CSC3=NCCN32)O1.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Jelenko C 3rd. Topical control of water loss from the body surface. 3. The effects of Furazolium Chloride (Novofur) and Furacin on membrane permeability: an in vitro study. J Surg Res. 1969 Jul;9(7):415-21. [Content Brief]
[2]. Snyder HR Jr, et al. IX. Some derivatives and analogs of 6,7-dihydro-3-(5-nitro-2-furyl)-5H-imidazo[2,1-b]thiazolium chloride. J Med Chem. 1970 Jan;13(1):164-5. [Content Brief]
[3]. Chung CW, et al. Induction of delayed hypersensitivity in guinea pigs by aflatoxins, other coumarins and furazolium. J Invest Dermatol. 1970 Dec;55(6):396-403. [Content Brief]
[4]. Javidan S, et al. Microbiological determination of drug partitioning. IV. Drug-protein interactions. Journal of pharmaceutical sciences. 1975 Mar;64(3):420-4. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Furazolium hydrochloride Related Classifications
HY-184081 Related Classifications
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