5118-17-2
Chemical Structure
Furazolium hydrochloride
- CAS No.: 5118-17-2
- Formula:C9H8ClN3O3S
- Molecular Weight:273.70
InChIKey: FMPJXUZSXKJUQI-UHFFFAOYSA-N
SMILES: O=[N+]([O-])C1=CC=C(C2=CSC3=NCCN32)O1.Cl
Biological Activity: Furazolium hydrochloride is a broad-spectrum antibacterial agent with inhibitory activity against a variety of Gram-positive and Gram-negative Bacterial strains. In a gelatin-acacia complex coacervate system, Furazolium hydrochloride exhibits protein-binding properties, where protein binding dominates at low concentrations, while micellization occurs at high concentrations. Furazolium hydrochloride does not alter the water permeability of cellulose membranes, and it can induce delayed-type hypersensitivity reactions in guinea pigs, with cross-reactivity observed in animals sensitized with aflatoxin B1. Furazolium hydrochloride can be used in studies related to bacterial infections and local wound infections[1][2][3][4].
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Furazolium hydrochloride | Furazolium hydrochloride is a broad-spectrum antibacterial agent with inhibitory activity against a variety of Gram-positive and Gram-negative Bacterial strains. In a gelatin-acacia complex coacervate system, Furazolium hydrochloride exhibits protein-binding properties, where protein binding dominates at low concentrations, while micellization occurs at high concentrations. Furazolium hydrochloride does not alter the water permeability of cellulose membranes, and it can induce delayed-type hypersensitivity reactions in guinea pigs, with cross-reactivity observed in animals sensitized with aflatoxin B1. Furazolium hydrochloride can be used in studies related to bacterial infections and local wound infections. | |||||||||||||||||||||
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- [1]. Jelenko C 3rd. Topical control of water loss from the body surface. 3. The effects of Furazolium Chloride (Novofur) and Furacin on membrane permeability: an in vitro study. J Surg Res. 1969 Jul;9(7):415-21. [Content Brief]
- [2]. Snyder HR Jr, et al. IX. Some derivatives and analogs of 6,7-dihydro-3-(5-nitro-2-furyl)-5H-imidazo[2,1-b]thiazolium chloride. J Med Chem. 1970 Jan;13(1):164-5. [Content Brief]
- [3]. Chung CW, et al. Induction of delayed hypersensitivity in guinea pigs by aflatoxins, other coumarins and furazolium. J Invest Dermatol. 1970 Dec;55(6):396-403. [Content Brief]
- [4]. Javidan S, et al. Microbiological determination of drug partitioning. IV. Drug-protein interactions. Journal of pharmaceutical sciences. 1975 Mar;64(3):420-4. [Content Brief]
Keywords
