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Cat. No.: HY-121285

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Dioxadrol

Dioxadrol is an uncompetitive NMDA receptor (PCP binding site) antagonist, with a K_i value of 10.9 nM in pigs. Dioxadrol binds to the phencyclidine (PCP) binding site within the cation channel associated with the NMDA receptor, thereby blocking cation influx. Dioxadrol possesses local anesthetic, spasmolytic and central nervous system activities, including phencyclidine-like dissociative anesthetic properties. Dioxadrol can be used in the research of Alzheimer's disease, Parkinson's disease, Huntington's disease, HIV-associated dementia, multiple sclerosis, amyotrophic lateral sclerosis, neuropathic pain, ischemic stroke, central nervous system trauma, and epilepsy.

For research use only. We do not sell to patients.

CAS No.: 6495-46-1
Formula: C₂₀H₂₃NO₂
Molecular Weight:309.40

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Dioxadrol Chemical Structure

CAS No.: 6495-46-1

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- IC₅₀ & Target
- In Vitro
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Biological Activity

Description

IC₅₀ & Target^[1]

NMDA Receptor

10.9 nM (Ki)

All iGluR Isoforms :

In Vitro

Dioxadrol (compound dioxadrol ((±)-3)) (150 min) potently binds to the PCP binding site of NMDA receptors in porcine cerebral cortex membranes, with a K_i value of 10.9 nM. Its affinity is comparable to that of commercially available dextromethorphan, and it shows high selectivity against off-target receptors^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 6495-46-1
Molecular Weight 309.40
Formula C₂₀H₂₃NO₂
SMILES

C1(C2OC(C3=CC=CC=C3)(C4=CC=CC=C4)OC2)NCCCC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Banerjee A, et al. Synthesis and SAR studies of chiral non-racemic dexoxadrol analogues as uncompetitive NMDA receptor antagonists. Bioorganic & medicinal chemistry. 2010 Nov 15;18(22):7855-67. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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- In Vitro
Chemical Information
Purity & Documentation
References

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Dioxadrol

All iGluR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Dioxadrol Related Classifications

HY-121285 Related Classifications