6495-46-1
Chemical Structure
Dioxadrol
- CAS No.: 6495-46-1
- Formula:C20H23NO2
- Molecular Weight:309.40
IUPAC Name: 2-(2,2-diphenyl-1,3-dioxolan-4-yl)piperidine
InChIKey: HGKAMARNFGKMLC-UHFFFAOYSA-N
SMILES: C1(C2OC(C3=CC=CC=C3)(C4=CC=CC=C4)OC2)NCCCC1
Biological Activity: Dioxadrol is an uncompetitive NMDA receptor (PCP binding site) antagonist, with a Ki value of 10.9 nM in pigs. Dioxadrol binds to the phencyclidine (PCP) binding site within the cation channel associated with the NMDA receptor, thereby blocking cation influx. Dioxadrol possesses local anesthetic, spasmolytic and central nervous system activities, including phencyclidine-like dissociative anesthetic properties. Dioxadrol can be used in the research of Alzheimer's disease, Parkinson's disease, Huntington's disease, HIV-associated dementia, multiple sclerosis, amyotrophic lateral sclerosis, neuropathic pain, ischemic stroke, central nervous system trauma, and epilepsy[1].
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Dioxadrol | Dioxadrol is an uncompetitive NMDA receptor (PCP binding site) antagonist, with a Ki value of 10.9 nM in pigs. Dioxadrol binds to the phencyclidine (PCP) binding site within the cation channel associated with the NMDA receptor, thereby blocking cation influx. Dioxadrol possesses local anesthetic, spasmolytic and central nervous system activities, including phencyclidine-like dissociative anesthetic properties. Dioxadrol can be used in the research of Alzheimer's disease, Parkinson's disease, Huntington's disease, HIV-associated dementia, multiple sclerosis, amyotrophic lateral sclerosis, neuropathic pain, ischemic stroke, central nervous system trauma, and epilepsy. | |||||||||||||||||||||
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Keywords
