2. GPCR/G Protein Neuronal Signaling
  3. Neurokinin Receptor
  4. TAC 363

TAC 363 is a selective tachykinin NK-2 receptor antagonist. TAC 363 shows a rightward shift in the contractile response curve induced by Neurokinin A (HY-P0197) with a pA2 of 9.82. TAC 363 has a weak antagonistic effect on NK-1 receptors. TAC 363 can inhibit Neurokinin A-induced bronchoconstriction in guinea pigs with an ED50 of 0.3 mg/kg. TAC 363 can be used for the research of bronchial asthma.

For research use only. We do not sell to patients.

TAC 363

TAC 363 Chemical Structure

CAS No. : 172081-08-2

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TAC 363 Related Antibodies

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Description

TAC 363 is a selective tachykinin NK-2 receptor antagonist. TAC 363 shows a rightward shift in the contractile response curve induced by Neurokinin A (HY-P0197) with a pA2 of 9.82. TAC 363 has a weak antagonistic effect on NK-1 receptors. TAC 363 can inhibit Neurokinin A-induced bronchoconstriction in guinea pigs with an ED50 of 0.3 mg/kg. TAC 363 can be used for the research of bronchial asthma[1].

IC50 & Target[1]

Tachykinin NK2 Receptor

9.82 (pA2)

Molecular Weight

712.84

Formula

C38H48N8O6
CAS No.
SMILES

O=C(NCCOCC1=CC=CC=C1)N(CC2=CC=CC=C2)NC([C@@H](NC([C@H](CCC(N)=O)NC(NC(C)(C)C)=O)=O)CC3=CNC4=CC=CC=C34)=O
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Room temperature in continental US; may vary elsewhere.
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References
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TAC 363 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TAC 363172081-08-2TAC363TAC-363Neurokinin ReceptorNK receptorTachykinin receptorInhibitorinhibitorinhibit

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