1. GPCR/G Protein Neuronal Signaling
  2. Adrenergic Receptor
  3. 2-Methoxyidazoxan monohydrochloride

2-Methoxyidazoxan monohydrochloride  (Synonyms: RX821002 hydrochloride)

Cat. No.: HY-103197 Purity: 99.20%
COA Handling Instructions

2-Methoxyidazoxan monohydrochloride (RX821002 hydrochloride) is a highly selective alpha 2-adrenoceptor antagonist with little or no imidazoline antagonist effect. RX 821002 has markedly higher affinity for (guinea-pig) alpha 2D-adrenoceptors (pKd 9.7) than for (rabbit) alpha 2A-adrenoceptors (pKd 8.2).

For research use only. We do not sell to patients.

2-Methoxyidazoxan monohydrochloride Chemical Structure

2-Methoxyidazoxan monohydrochloride Chemical Structure

CAS No. : 109544-45-8

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5 mg USD 50 In-stock
10 mg USD 80 In-stock
50 mg USD 270 In-stock
100 mg USD 430 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

2-Methoxyidazoxan monohydrochloride (RX821002 hydrochloride) is a highly selective alpha 2-adrenoceptor antagonist with little or no imidazoline antagonist effect. RX 821002 has markedly higher affinity for (guinea-pig) alpha 2D-adrenoceptors (pKd 9.7) than for (rabbit) alpha 2A-adrenoceptors (pKd 8.2)[1][2].

In Vivo

2-Methoxyidazoxan monohydrochloride (1 mg/kg) enhances locomotion in the novel environment, particularly in neonatal ventral hippocampal lesion (NVHL) rats. RX82100 has a biphasic effect on locomotion, consisting of an initial reduction preceding the enhancement[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

270.71

Formula

C12H15ClN2O3

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

COC1(C2=NCCN2)OC3=CC=CC=C3OC1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (369.40 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6940 mL 18.4699 mL 36.9399 mL
5 mM 0.7388 mL 3.6940 mL 7.3880 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (184.70 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.6940 mL 18.4699 mL 36.9399 mL 92.3497 mL
5 mM 0.7388 mL 3.6940 mL 7.3880 mL 18.4699 mL
10 mM 0.3694 mL 1.8470 mL 3.6940 mL 9.2350 mL
15 mM 0.2463 mL 1.2313 mL 2.4627 mL 6.1566 mL
20 mM 0.1847 mL 0.9235 mL 1.8470 mL 4.6175 mL
25 mM 0.1478 mL 0.7388 mL 1.4776 mL 3.6940 mL
30 mM 0.1231 mL 0.6157 mL 1.2313 mL 3.0783 mL
40 mM 0.0923 mL 0.4617 mL 0.9235 mL 2.3087 mL
50 mM 0.0739 mL 0.3694 mL 0.7388 mL 1.8470 mL
60 mM 0.0616 mL 0.3078 mL 0.6157 mL 1.5392 mL
80 mM 0.0462 mL 0.2309 mL 0.4617 mL 1.1544 mL
100 mM 0.0369 mL 0.1847 mL 0.3694 mL 0.9235 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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2-Methoxyidazoxan monohydrochloride Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
2-Methoxyidazoxan monohydrochloride
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HY-103197
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