country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-19249

Copy Link Print Information

Z-335 sodium

Z-335 sodium is an orally active thromboxane a₂ (TXA₂) receptor antagonist, with IC₅₀ values of 29.9 nM and 32.5 nM for human and Guinea pig platelets, respectively.

For research use only. We do not sell to patients.

CAS No.: 146731-14-8
Formula: C₁₈H₁₇ClNNaO₄S
Molecular Weight:401.84

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

Z-335 sodium Chemical Structure

CAS No.: 146731-14-8

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Z-335 sodium is an orally active thromboxane a₂ (TXA₂) receptor antagonist, with IC₅₀ values of 29.9 nM and 32.5 nM for human and Guinea pig platelets, respectively^[1]^[2].

All Prostaglandin Receptor Isoforms :

In Vivo

Z-335 (0.3-3 mg/kg, p.o.) inhibits thrombus formation in a dose-dependent manner^[2].
Z-335 (3 mg/kg, p.o.) significantly prevents thrombus formation even at 16 h ^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 146731-14-8
Molecular Weight 401.84
Formula C₁₈H₁₇ClNNaO₄S
SMILES

O=C(CC1=CC=C2C(CC(C2)CNS(=O)(C3=CC=C(C=C3)Cl)=O)=C1)O[Na]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. T Tanaka, et al. Antiplatelet effect of Z-335, a new orally active and long-lasting thromboxane receptor antagonist. Eur J Pharmacol. 1998 Sep 11;357(1):53-60. [Content Brief]

[2]. T Tanaka, et al. Z-335, a new thromboxane A(2) receptor antagonist, prevents arterial thrombosis induced by ferric chloride in rats. Eur J Pharmacol. 2000 Aug 11;401(3):413-8. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote