146731-14-8
146731-14-8
Chemical Structure
Z-335 sodium
- CAS No.: 146731-14-8
- Formula:C18H17ClNNaO4S
- Molecular Weight:401.84
IUPAC Name: 2-(2-((4-chlorophenylsulfonamido)methyl)-2,3-dihydro-1H-inden-5-yl)acetic acid, sodium salt
InChIKey: UEPBEZPJELQKJV-UHFFFAOYSA-N
SMILES: O=C(CC1=CC=C2C(CC(C2)CNS(=O)(C3=CC=C(C=C3)Cl)=O)=C1)O[Na]
Biological Activity: Z-335 sodium is an orally active thromboxane a2 (TXA2) receptor antagonist, with IC50 values of 29.9 nM and 32.5 nM for human and Guinea pig platelets, respectively[1][2].
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Z-335 sodium | Z-335 sodium is an orally active thromboxane a2 (TXA2) receptor antagonist, with IC50 values of 29.9 nM and 32.5 nM for human and Guinea pig platelets, respectively. | |||||||||||||||||||||
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References
- [1]. T Tanaka, et al. Antiplatelet effect of Z-335, a new orally active and long-lasting thromboxane receptor antagonist. Eur J Pharmacol. 1998 Sep 11;357(1):53-60. [Content Brief]
- [2]. T Tanaka, et al. Z-335, a new thromboxane A(2) receptor antagonist, prevents arterial thrombosis induced by ferric chloride in rats. Eur J Pharmacol. 2000 Aug 11;401(3):413-8. [Content Brief]
Keywords
