Tyr-Ala-N-(1,3-dimethylbutyl)glycinamide 

Tyr-Ala-N-(1,3-dimethylbutyl)glycinamide is a μ/δ opioid receptor ligand with high μ opioid receptor selectivity and agonist activity. Tyr-Ala-N-(1,3-dimethylbutyl)glycinamide has an IC₅₀ of 237 nM for μ receptors and 1050 nM for δ receptors. Tyr-Ala-N-(1,3-dimethylbutyl)glycinamide shows K_i values of 17 nM for μ receptors and 480 nM for δ receptors. Tyr-Ala-N-(1,3-dimethylbutyl)glycinamide inhibits electrically evoked contractions of guinea pig ileum and mouse vas deferens. Tyr-Ala-N-(1,3-dimethylbutyl)glycinamide serves as a starting compound for structure-activity relationship investigations of μ receptor recognition^[1].

Tyr-Ala-N-(1,3-dimethylbutyl)glycinamide (TRIMU 4) inhibits electrically evoked contractions of guinea pig ileum with an IC₅₀ of 237 nM, indicating activity at μ opioid receptors^[1].
Tyr-Ala-N-(1,3-dimethylbutyl)glycinamide inhibits electrically evoked contractions of mouse vas deferens with an IC₅₀ of 1050 nM, with a 4.35-fold preference for μ over δ opioid receptors^[1].
Tyr-Ala-N-(1,3-dimethylbutyl)glycinamide (40 min) inhibits binding of the μ-selective ligand [³H]DAGO to rat brain membrane μ opioid receptors with a K_i of 17.0 nM^[1].
Tyr-Ala-N-(1,3-dimethylbutyl)glycinamide (40 min) inhibits binding of the δ-selective ligand [³H]DSLET to rat brain membrane δ opioid receptors with a K_i of 480 nM, with a 28-fold preference for μ over δ opioid receptors^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

392.49

C₂₀H₃₂N₄O₄

72732-17-3

CC(C)CC(C)NC(CNC([C@@H](C)NC([C@@H](N)CC1=CC=C(C=C1)O)=O)=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Gacel G. Investigation of the structural parameters involved in the mu and delta opioid receptor discrimination of linear enkephalin-related peptides. J Med Chem. 1988 Feb;31(2):374-83.