Tyr-Ala-N-(1,3-dimethylbutyl)glycinamide
Tyr-Ala-N-(1,3-dimethylbutyl)glycinamide is a μ/δ opioid receptor ligand with high μ opioid receptor selectivity and agonist activity. Tyr-Ala-N-(1,3-dimethylbutyl)glycinamide has an IC50 of 237 nM for μ receptors and 1050 nM for δ receptors. Tyr-Ala-N-(1,3-dimethylbutyl)glycinamide shows Ki values of 17 nM for μ receptors and 480 nM for δ receptors. Tyr-Ala-N-(1,3-dimethylbutyl)glycinamide inhibits electrically evoked contractions of guinea pig ileum and mouse vas deferens. Tyr-Ala-N-(1,3-dimethylbutyl)glycinamide serves as a starting compound for structure-activity relationship investigations of μ receptor recognition.
For research use only. We do not sell to patients.
- CAS No.: 72732-17-3
- Formula: C20H32N4O4
- Molecular Weight:392.49
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Biological Activity
Description
IC50 & Target
[1]|
μ Opioid Receptor/MOR 237 nM (IC50) |
δ Opioid Receptor/DOR 1050 nM (IC50) |
μ Opioid Receptor/MOR 17 nM (Ki) |
δ Opioid Receptor/DOR 480 nM (Ki) |
In Vitro
Tyr-Ala-N-(1,3-dimethylbutyl)glycinamide (TRIMU 4) inhibits electrically evoked contractions of guinea pig ileum with an IC50 of 237 nM, indicating activity at μ opioid receptors[1].
Tyr-Ala-N-(1,3-dimethylbutyl)glycinamide inhibits electrically evoked contractions of mouse vas deferens with an IC50 of 1050 nM, with a 4.35-fold preference for μ over δ opioid receptors[1].
Tyr-Ala-N-(1,3-dimethylbutyl)glycinamide (40 min) inhibits binding of the μ-selective ligand [3H]DAGO to rat brain membrane μ opioid receptors with a Ki of 17.0 nM[1].
Tyr-Ala-N-(1,3-dimethylbutyl)glycinamide (40 min) inhibits binding of the δ-selective ligand [3H]DSLET to rat brain membrane δ opioid receptors with a Ki of 480 nM, with a 28-fold preference for μ over δ opioid receptors[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 72732-17-3
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Molecular Weight 392.49
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Formula C20H32N4O4
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SMILES
CC(C)CC(C)NC(CNC([C@@H](C)NC([C@@H](N)CC1=CC=C(C=C1)O)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tyr-Ala-N-(1,3-dimethylbutyl)glycinamide Related Classifications
HY-182563 Related Classifications
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