Aspalathin 

Aspalathin is a C-glycosyldihydrochalcone flavonoid and antioxidant.Aspalathin functions as an antimutagen.Aspalathin can be absorbed by pig intestine as a C-glycoside, and can also be cleaved into its aglycone and sugar moiety.Aspalathin is found in Aspalathus linearis (rooibos)^[1].

Aspalathin (5 μg/mL) with optimized β-D-glucuronidase treatment (2096 U/mL for urine; 4611.2 U/mL for plasma) and SPE cleanup procedures achieves measurable recovery of aspalathin from spiked blank urine and plasma samples, with plasma showing higher recovery and variable precision depending on enzymatic treatment. Incubation times were 3 h for urine and 1 h for plasma enzymatic treatment^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Aspalathin (157-167 mg/kg body weight; p.o.; daily; 11 days) is absorbed in pigs as a C-glycoside and undergoes phase II metabolism to form methylated and glucuronidated conjugates, with 0.1-0.9% of the administered dose excreted in urine, while no aspalathin or metabolites are detectable in plasma^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

452.41

C₂₁H₂₄O₁₁

6027-43-6

O[C@H]1[C@H](C2=C(C(C(CCC3=CC(O)=C(C=C3)O)=O)=C(C=C2O)O)O)O[C@@H]([C@H]([C@@H]1O)O)CO

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Kreuz S, et al. Aspalathin, a flavonoid in Aspalathus linearis (rooibos), is absorbed by pig intestine as a C-glycoside. Nutr Res. 2008;28(10):690-701.  [Content Brief]