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製品番号: HY-N11738

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Aspalathin

Aspalathin is a C-glycosyldihydrochalcone flavonoid and antioxidant.Aspalathin functions as an antimutagen.Aspalathin can be absorbed by pig intestine as a C-glycoside, and can also be cleaved into its aglycone and sugar moiety.Aspalathin is found in Aspalathus linearis (rooibos).

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 6027-43-6
分子式: C₂₁H₂₄O₁₁
分子量:452.41

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Aspalathin 構造式

CAS 番号: 6027-43-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

Aspalathin (5 μg/mL) with optimized β-D-glucuronidase treatment (2096 U/mL for urine; 4611.2 U/mL for plasma) and SPE cleanup procedures achieves measurable recovery of aspalathin from spiked blank urine and plasma samples, with plasma showing higher recovery and variable precision depending on enzymatic treatment. Incubation times were 3 h for urine and 1 h for plasma enzymatic treatment^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Aspalathin (157-167 mg/kg body weight; p.o.; daily; 11 days) is absorbed in pigs as a C-glycoside and undergoes phase II metabolism to form methylated and glucuronidated conjugates, with 0.1-0.9% of the administered dose excreted in urine, while no aspalathin or metabolites are detectable in plasma^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Female Pig (6 months old, 94-99 kg)^[1]
Dosage:

157 mg/kg ; 167 mg/kg
Administration:

p.o.; daily; 11 days
Result:

Identified six substances derived from aspalathin in urine: parent aspalathin, methylated aspalathin, glucuronidated aspalathin, glucuronidated and methylated aspalathin, a glucuronidated aglycone of aspalathin, and a methylated eriodictyol metabolite with two glucuronic acid moieties.
Detected methylated aspalathin as the major metabolite in enzymatically treated urine samples.

化学情報

CAS 番号 6027-43-6
分子量 452.41
分子式 C₂₁H₂₄O₁₁
SMILES

O[C@H]1[C@H](C2=C(C(C(CCC3=CC(O)=C(C=C3)O)=O)=C(C=C2O)O)O)O[C@@H]([C@H]([C@@H]1O)O)CO
Structure Classification
- Phenols
- Polyphenols
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (270 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Kreuz S, et al. Aspalathin, a flavonoid in Aspalathus linearis (rooibos), is absorbed by pig intestine as a C-glycoside. Nutr Res. 2008;28(10):690-701. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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