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Cat. No.: HY-117811

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(R,R)-MK 287

Name: (R,R)-MK 287
Brand: MedChemExpress
SKU: HY-117811
Availability: PreOrder

(Synonyms: L-680574)

(R,R)-MK 287 (L-680574) is a tetrahydrofuran derivative that potently inhibits the binding of [3H]C18-PAF to human platelets, polymorphonuclear leukocytes (PMNs), and lung membranes with Ki values of 6.1, 3.2, and 5.49 nM, respectively. (R,R)-MK 287 potently and selectively inhibits PAF-induced platelet aggregation (ED₅₀=56 nM) and elastase release from PMNs (ED₅₀=4.4 nM). (R,R)-MK 287 inhibits PAF-induced lethality in mice (ED₅₀=0.8 mg/kg, po) and PAF-induced bronchospasm in guinea pigs (ED₅₀=0.18 mg/kg).

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CAS No.: 143490-81-7
Formule: C₂₅H₃₄O₉S
Masse moléculaire:510.60

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

(R,R)-MK 287 Chemical Structure

CAS No.: 143490-81-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Description

Chemical Information

CAS No. 143490-81-7
Masse moléculaire 510.60
Formule C₂₅H₃₄O₉S
SMILES

CCCOC1=C(C=C([C@@H]2O[C@@H](C3=CC(OC)=C(C(OC)=C3)OC)CC2)C=C1OC)S(CCO)(=O)=O
Synonyms

L-680574
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Hwang S B, et al. MK 287: a potent, specific, and orally active receptor antagonist of platelet-activating factor[J]. Journal of lipid mediators, 1993, 7(2): 115-134. [Content Brief]

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1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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