1. GPCR/G Protein
    Neuronal Signaling
  2. Neurokinin Receptor
  3. FK888

FK888 

Cat. No.: HY-105215
Handling Instructions

FK888 is a potent, selective, and high affinity dipeptide NK1 receptor antagonist. FK888 displaces [3H]-SP binding with a Ki value of 0.69 nM and 0.45 microM. FK888 also inhibits SP-induced airway oedema in guinea-pig after both intravenous and oral administration.

For research use only. We do not sell to patients.

FK888 Chemical Structure

FK888 Chemical Structure

CAS No. : 138449-07-7

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Description

FK888 is a potent, selective, and high affinity dipeptide NK1 receptor antagonist. FK888 displaces [3H]-SP binding with a Ki value of 0.69 nM and 0.45 microM. FK888 also inhibits SP-induced airway oedema in guinea-pig after both intravenous and oral administration[1].

Molecular Weight

588.70

Formula

C36H36N4O4

CAS No.
SMILES

O=C(N(C[[email protected]@H]1O)[[email protected]@H](C1)C(N[[email protected]](C(N(C)CC2=CC=CC=C2)=O)CC3=CC(C=CC=C4)=C4C=C3)=O)C(C5=CC=CC=C56)=CN6C

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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FK888
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