138449-07-7
Chemical Structure
FK888
- CAS No.: 138449-07-7
- Formula:C36H36N4O4
- Molecular Weight:588.70
IUPAC Name: (2S,4R)-N-((S)-1-(benzyl(methyl)amino)-3-(naphthalen-2-yl)-1-oxopropan-2-yl)-4-hydroxy-1-(1-methyl-1H-indole-3-carbonyl)pyrrolidine-2-carboxamide
InChIKey: BFNKQTIJVFGCKQ-PDJGWCFMSA-N
SMILES: O=C(N(C[C@@H]1O)[C@@H](C1)C(N[C@H](C(N(C)CC2=CC=CC=C2)=O)CC3=CC(C=CC=C4)=C4C=C3)=O)C(C5=CC=CC=C56)=CN6C
Biological Activity: FK888 is a potent, selective, and high affinity dipeptide NK1 receptor antagonist. FK888 displaces [3H]-SP binding with a Ki value of 0.69 nM and 0.45 microM. FK888 also inhibits SP-induced airway oedema in guinea-pig after both intravenous and oral administration[1].
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FK888 | FK888 is a potent, selective, and high affinity dipeptide NK1 receptor antagonist. FK888 displaces [3H]-SP binding with a Ki value of 0.69 nM and 0.45 microM. FK888 also inhibits SP-induced airway oedema in guinea-pig after both intravenous and oral administration. | |||||||||||||||||||||
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