Ethaverine hydrochloride 

Ethaverine hydrochloride, a derivative of papaverine, inhibits cardiac L-type calcium channel. Ethaverine hydrochloride is a peripheral vasodilator and antispasmodic agent. Ethaverine hydrochloride can be used for research of peripheral vascular disease^[1][2][3].

Ethaverine hydrochloride (10 μM, PC12 cells) reduces catecholamine secretion by blocking the L-type voltage-sensitive Ca²⁺ channel^[2].
Ethaverine hydrochloride (12 h) decreases dopamine content by inhibiting tyrosine hydroxylase (TH) activity in PC12 cells, with an IC₅₀ of 1.4 μM^[3].
Ethaverine hydrochloride inhibits monoamine oxidase (MAO) activity in mouse brain (isolated from mouse whole brain), with an IC₅₀ of 25.5 μM^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ethaverine hydrochloride (2-10 mg/kg, intravenous infusion, i.v.) causes significant elevation of endocochlear potential in guinea pigs^[4].
Ethaverine (1-10 mg/kg, i.v.) inhibits atrioventricular conduction and heart rate in the anaesthetized dog^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

431.95

C₂₄H₃₀ClNO₄

985-13-7

Solid

Light yellow to yellow

CCOC1=CC2=C(C=C1OCC)C=CN=C2CC3=CC=C(OCC)C(OCC)=C3.[H]Cl

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. Wang Y, et al. Ethaverine, a derivative of papaverine, inhibits cardiac L-type calcium channels. Mol Pharmacol. 1991 Nov;40(5):750-5.  [Content Brief]

  [2]. Suh BC, et al. Inhibition by ethaverine of catecholamine secretion through blocking L-type Ca2+ channels in PC12 cells. Biochem Pharmacol. 1994 Mar 29;47(7):1262-6.  [Content Brief]

  [3]. Shin JS, et al. Inhibitory effects of ethaverine, a homologue of papaverine, on dopamine content in PC12 cells. Biol Pharm Bull. 2001 Jan;24(1):103-5.  [Content Brief]

  [4]. Prazma J, et al. Effect of ethaverine hydrochloride on cochlear microcirculation. Arch Otolaryngol. 1981 Apr;107(4):227-9.  [Content Brief]

  [5]. Lacroix P, et al. [Comparative activity of ethaverine and papaverine on chronotropic and dromotropic cardiac functions in the anesthetized dog]. Arch Int Pharmacodyn Ther. 1976 May;221(1):163-76. French.  [Content Brief]

  [6]. Lee SS, et al. Inhibitory effects of ethaverine, a homologue of papaverine, on monoamine oxidase activity in mouse brain. Biol Pharm Bull. 2001 Jul;24(7):838-40.  [Content Brief]