Ethaverine hydrochloride (Standard)
Ethaverine hydrochloride (Standard) is the analytical standard of Ethaverine hydrochloride (HY-B1440). This product is intended for research and analytical applications. Ethaverine hydrochloride is a Papaverine derivative and vasodilator. Ethaverine hydrochloride inhibits Phosphodiesterase, Tyrosine hydroxylase, and MAO-B. Ethaverine hydrochloride blocks L-type Ca2+ channels, reduces intracellular Ca2+ levels, inhibits platelet adhesion and aggregation, regulates cardiac conduction and heart rate, and increases peripheral and cerebral blood flow. Ethaverine hydrochloride alters cochlear microcirculation, intracochlear Po2, CM potential, and EP in guinea pigs, and induces transient hypotension. Ethaverine hydrochloride is used in the research of peripheral vascular diseases.
For research use only. We do not sell to patients.
- CAS No.: 985-13-7
- Formula: C24H30ClNO4
- Molecular Weight:431.95
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Product Information
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 985-13-7
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Molecular Weight 431.95
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Formula C24H30ClNO4
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SMILES
CCOC1=CC2=C(C=C1OCC)C=CN=C2CC3=CC=C(OCC)C(OCC)=C3.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Lee SS, et al. Inhibitory effects of ethaverine, a homologue of papaverine, on monoamine oxidase activity in mouse brain. Biological & pharmaceutical bulletin. 2001 Jul;24(7):838-40. [Content Brief]
[2]. Shin JS, et al. Inhibitory effects of ethaverine, a homologue of papaverine, on dopamine content in PC12 cells. Biological & pharmaceutical bulletin. 2001 Jan;24(1):103-5. [Content Brief]
[3]. Prazma J, et al. Effect of ethaverine hydrochloride on cochlear microcirculation. Archives of otolaryngology (Chicago, Ill. : 1960). 1981 Apr;107(4):227-9. [Content Brief]
[4]. Wang Y, et al. Ethaverine, a derivative of papaverine, inhibits cardiac L-type calcium channels. Molecular pharmacology. 1991 Nov;40(5):750-5. [Content Brief]
[5]. Suh BC, et al. Inhibition by ethaverine of catecholamine secretion through blocking L-type Ca2+ channels in PC12 cells. Biochemical pharmacology. 1994 Mar 29;47(7):1262-6. [Content Brief]
[6]. Lacroix P, et al. Activit comparée de l'ethavérine et de la papavérine sur les fonctions cardiaques chronotrope et dromotrope chez le chien anesthésié [Comparative activity of ethaverine and papaverine on chronotropic and dromotropic cardiac functions in the anesthetized dog]. Arch Int Pharmacodyn Ther. 1976 May;221(1):163-76. French. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
- Ethaverine hydrochloride (Standard)
- 985-13-7
- Reference Standards
- Drug Derivative
- Phosphodiesterase (PDE)
- Calcium Channel
- Tyrosine Hydroxylase
- Monoamine Oxidase
- porcine cardiac sarcolemma membranes
- guinea pigs
- porcine cardiac L-type Ca++ channel
- MAO
- tyrosine hydroxylase
- phosphodiesterase
- MAO-B
- PC12 cells
- anesthetized dogs
- neural cells
- Inhibitor
- inhibitor
- inhibit