985-13-7
Chemical Structure
Ethaverine hydrochloride
- CAS No.: 985-13-7
- Formula:C24H30ClNO4
- Molecular Weight:431.95
IUPAC Name: 1-(3,4-diethoxybenzyl)-6,7-diethoxyisoquinoline hydrochloride
InChIKey: UPUDVKWQBVIKBG-UHFFFAOYSA-N
SMILES: CCOC1=CC2=C(C=C1OCC)C=CN=C2CC3=CC=C(OCC)C(OCC)=C3.[H]Cl
Biological Activity: Ethaverine hydrochloride is a Papaverine derivative and vasodilator. Ethaverine hydrochloride inhibits Phosphodiesterase, Tyrosine hydroxylase, and MAO-B. Ethaverine hydrochloride blocks L-type Ca2+ channels, reduces intracellular Ca2+ levels, inhibits platelet adhesion and aggregation, regulates cardiac conduction and heart rate, and increases peripheral and cerebral blood flow. Ethaverine hydrochloride alters cochlear microcirculation, intracochlear Po2, CM potential, and EP in guinea pigs, and induces transient hypotension. Ethaverine hydrochloride is used in the research of peripheral vascular diseases[1][2][3][4][5][6].
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Ethaverine hydrochloride | 99.72% | Ethaverine hydrochloride is a Papaverine derivative and vasodilator. Ethaverine hydrochloride inhibits Phosphodiesterase, Tyrosine hydroxylase, and MAO-B. Ethaverine hydrochloride blocks L-type Ca2+ channels, reduces intracellular Ca2+ levels, inhibits platelet adhesion and aggregation, regulates cardiac conduction and heart rate, and increases peripheral and cerebral blood flow. Ethaverine hydrochloride alters cochlear microcirculation, intracochlear Po2, CM potential, and EP in guinea pigs, and induces transient hypotension. Ethaverine hydrochloride is used in the research of peripheral vascular diseases. | ||||||||||||||||||||
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Ethaverine hydrochloride (Standard) | ≥98% | Ethaverine hydrochloride (Standard) is the analytical standard of Ethaverine hydrochloride (HY-B1440). This product is intended for research and analytical applications. Ethaverine hydrochloride is a Papaverine derivative and vasodilator. Ethaverine hydrochloride inhibits Phosphodiesterase, Tyrosine hydroxylase, and MAO-B. Ethaverine hydrochloride blocks L-type Ca2+ channels, reduces intracellular Ca2+ levels, inhibits platelet adhesion and aggregation, regulates cardiac conduction and heart rate, and increases peripheral and cerebral blood flow. Ethaverine hydrochloride alters cochlear microcirculation, intracochlear Po2, CM potential, and EP in guinea pigs, and induces transient hypotension. Ethaverine hydrochloride is used in the research of peripheral vascular diseases. | ||||||||||||||||||||
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Similarity Score 0.61
HY-176892APapaveroline hydrochloride -
Similarity Score 0.60
HY-176892Papaveroline -
Similarity Score 0.60
HY-118392Papaveraldine -
Similarity Score 0.59
HY-W277805Octaverine -
Similarity Score 0.54
HY-117587EHT-6706 free base -
Similarity Score 0.50
HY-148323Anti-Trypanosoma cruzi agent-4 -
Similarity Score 0.50
HY-114743GS 283 -
Similarity Score 0.49
HY-118581Coralyne chloride -
Similarity Score 0.48
HY-100928YS 035 hydrochloride -
Explore the MedChemAI to find more analogs
References
- [1]. Lee SS, et al. Inhibitory effects of ethaverine, a homologue of papaverine, on monoamine oxidase activity in mouse brain. Biological & pharmaceutical bulletin. 2001 Jul;24(7):838-40. [Content Brief]
- [2]. Shin JS, et al. Inhibitory effects of ethaverine, a homologue of papaverine, on dopamine content in PC12 cells. Biological & pharmaceutical bulletin. 2001 Jan;24(1):103-5. [Content Brief]
- [3]. Prazma J, et al. Effect of ethaverine hydrochloride on cochlear microcirculation. Archives of otolaryngology (Chicago, Ill. : 1960). 1981 Apr;107(4):227-9. [Content Brief]
- [4]. Wang Y, et al. Ethaverine, a derivative of papaverine, inhibits cardiac L-type calcium channels. Molecular pharmacology. 1991 Nov;40(5):750-5. [Content Brief]
- [5]. Suh BC, et al. Inhibition by ethaverine of catecholamine secretion through blocking L-type Ca2+ channels in PC12 cells. Biochemical pharmacology. 1994 Mar 29;47(7):1262-6. [Content Brief]
- [6]. Lacroix P, et al. Activit comparée de l'ethavérine et de la papavérine sur les fonctions cardiaques chronotrope et dromotrope chez le chien anesthésié [Comparative activity of ethaverine and papaverine on chronotropic and dromotropic cardiac functions in the anesthetized dog]. Arch Int Pharmacodyn Ther. 1976 May;221(1):163-76. French. [Content Brief]
