1. Cell Cycle/DNA Damage
  2. Topoisomerase
  3. Coralyne chloride

Coralyne chloride 

Cat. No.: HY-118581
Handling Instructions

Coralyne chloride is a protoberberine alkaloid with potent anti-cancer activities. Coralyne chloride acts as a potent topoisomerase I poison and induces Top I mediated DNA cleavage. Coralyne chloride can be used for preparing coralyne derivatives as DNA binding fluorescent probes.

For research use only. We do not sell to patients.

Coralyne chloride Chemical Structure

Coralyne chloride Chemical Structure

CAS No. : 38989-38-7

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Description

Coralyne chloride is a protoberberine alkaloid with potent anti-cancer activities. Coralyne chloride acts as a potent topoisomerase I poison and induces Top I mediated DNA cleavage[2]. Coralyne chloride can be used for preparing coralyne derivatives as DNA binding fluorescent probes[3].

IC50 & Target[1]

Topoisomerase I

 

In Vitro

Coralyne (6.25-100 μM; 24-72 hours) has cytotoxicity effect on breast cancer cell lines. It against MCF-7, MDA-MB-231 and MCF-10A cells with IC50s of 76.4 uM, 76.4 uM, and 99 uM,respectively at 24 hours. And it against MCF-7, MDA-MB-231 and MCF-10A cells with IC50s of 21.9 uM, 19.1 uM, and 91 μM, respectively at 72 hours[1].
Coralyne (25 μM; 48 hours) significantly downregulates cancer cell attachment of MCF-7 and MDA-MB-231 compared to the untreated controls. The percent of reduction in adhesion of MCF-7 is 55%, whereas 53% in reduction in the adhesion of MDA-MB-23 and 62% in reduction of MCF-10A,respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

399.87

Formula

C₂₂H₂₂ClNO₄

CAS No.
SMILES

CC1=C2C=C(C(OC)=CC2=CC3=C4C=C(C(OC)=CC4=CC=[N+]13)OC)OC.[Cl-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
References
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Keywords:

CoralyneTopoisomeraseAntileukemicneurodrugtopoisomerase IcancerprotoberberineInhibitorinhibitorinhibit

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Coralyne chloride
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HY-118581
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