1. Cell Cycle/DNA Damage
  2. Topoisomerase
  3. Coralyne chloride

Coralyne chloride 

Cat. No.: HY-118581 Purity: 99.34%
Handling Instructions

Coralyne chloride is a protoberberine alkaloid with potent anti-cancer activities. Coralyne chloride acts as a potent topoisomerase I poison and induces Top I mediated DNA cleavage. Coralyne chloride can be used for preparing coralyne derivatives as DNA binding fluorescent probes.

For research use only. We do not sell to patients.

Coralyne chloride Chemical Structure

Coralyne chloride Chemical Structure

CAS No. : 38989-38-7

Size Price Stock Quantity
5 mg USD 90 In-stock
Estimated Time of Arrival: December 31
10 mg USD 160 In-stock
Estimated Time of Arrival: December 31
25 mg USD 350 In-stock
Estimated Time of Arrival: December 31
50 mg USD 550 In-stock
Estimated Time of Arrival: December 31
100 mg USD 950 In-stock
Estimated Time of Arrival: December 31
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Description

Coralyne chloride is a protoberberine alkaloid with potent anti-cancer activities. Coralyne chloride acts as a potent topoisomerase I poison and induces Top I mediated DNA cleavage[2]. Coralyne chloride can be used for preparing coralyne derivatives as DNA binding fluorescent probes[3].

IC50 & Target[1]

Topoisomerase I

 

In Vitro

Coralyne (6.25-100 μM; 24-72 hours) has cytotoxicity effect on breast cancer cell lines. It against MCF-7, MDA-MB-231 and MCF-10A cells with IC50s of 76.4 uM, 76.4 uM, and 99 uM,respectively at 24 hours. And it against MCF-7, MDA-MB-231 and MCF-10A cells with IC50s of 21.9 uM, 19.1 uM, and 91 μM, respectively at 72 hours[1].
Coralyne (25 μM; 48 hours) significantly downregulates cancer cell attachment of MCF-7 and MDA-MB-231 compared to the untreated controls. The percent of reduction in adhesion of MCF-7 is 55%, whereas 53% in reduction in the adhesion of MDA-MB-23 and 62% in reduction of MCF-10A,respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

399.87

Formula

C22H22ClNO4

CAS No.
SMILES

CC1=C2C=C(C(OC)=CC2=CC3=C4C=C(C(OC)=CC4=CC=[N+]13)OC)OC.[Cl-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 4 mg/mL (10.00 mM; ultrasonic and warming and heat to 60°C)

DMSO : 1.82 mg/mL (4.55 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5008 mL 12.5041 mL 25.0081 mL
5 mM 0.5002 mL 2.5008 mL 5.0016 mL
10 mM 0.2501 mL 1.2504 mL 2.5008 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 99.34%

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Coralyne chloride
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HY-118581
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