Coralyne chloride

Name: Coralyne chloride
Brand: MedChemExpress
SKU: HY-118581
Rating: 4.5 (1 reviews)

Cat. No.: HY-118581 Purity: 99.34%: FAQs
Data Sheet SDS COA Handling Instructions

Coralyne chloride is a protoberberine alkaloid with potent anti-cancer activities. Coralyne chloride acts as a potent topoisomerase I poison and induces Top I mediated DNA cleavage. Coralyne chloride can be used for preparing coralyne derivatives as DNA binding fluorescent probes.

For research use only. We do not sell to patients.

Coralyne chloride Chemical Structure

CAS No. : 38989-38-7

Size	Price	Stock	Quantity
1 mg	USD 42	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 90	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 160	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 350	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 550	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 950	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Topoisomerase Isoform Specific Products:

View All Isoforms

Topoisomerase Topo I Topo II

Biological Activity
Purity & Documentation
References
Customer Review

Description

Coralyne chloride is a protoberberine alkaloid with potent anti-cancer activities. Coralyne chloride acts as a potent topoisomerase I poison and induces Top I mediated DNA cleavage^[2]. Coralyne chloride can be used for preparing coralyne derivatives as DNA binding fluorescent probes^[3].

IC₅₀ & Target^[1]

Topoisomerase I

In Vitro

Coralyne (6.25-100 μM; 24-72 hours) has cytotoxicity effect on breast cancer cell lines. It against MCF-7, MDA-MB-231 and MCF-10A cells with IC₅₀s of 76.4 uM, 76.4 uM, and 99 uM,respectively at 24 hours. And it against MCF-7, MDA-MB-231 and MCF-10A cells with IC₅₀s of 21.9 uM, 19.1 uM, and 91 μM, respectively at 72 hours^[1].
Coralyne (25 μM; 48 hours) significantly downregulates cancer cell attachment of MCF-7 and MDA-MB-231 compared to the untreated controls. The percent of reduction in adhesion of MCF-7 is 55%, whereas 53% in reduction in the adhesion of MDA-MB-23 and 62% in reduction of MCF-10A,respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

399.87

Appearance

Solid

Formula

C₂₂H₂₂ClNO₄

CAS No.

38989-38-7

SMILES

CC1=C2C=C(C(OC)=CC2=CC3=C4C=C(C(OC)=CC4=CC=[N+]13)OC)OC.[Cl-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 4 mg/mL (10.00 mM; ultrasonic and warming and heat to 60°C)

DMSO : 1.82 mg/mL (4.55 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5008 mL	12.5041 mL	25.0081 mL
5 mM	0.5002 mL	2.5008 mL	5.0016 mL
10 mM	0.2501 mL	1.2504 mL	2.5008 mL

*Please refer to the solubility information to select the appropriate solvent.

Purity & Documentation

Purity: 99.34%

Select Batch:

Data Sheet (274 KB) SDS (251 KB)

COA (250 KB) HNMR (277 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

References

[1]. Seema Kumari, et al. Synergistic effects of coralyne and paclitaxel on cell migration and proliferation of breast cancer cells lines. Biomed Pharmacother. 2017 Jul;91:436-445. [Content Brief]

[2]. D Makhey, et al. Coralyne and related compounds as mammalian topoisomerase I and topoisomerase II poisons. Bioorg Med Chem. 1996 Jun;4(6):781-91. [Content Brief]

[3]. P M Pithan, et al. 8-Styryl-substituted coralyne derivatives as DNA binding fluorescent probes.RSC Adv. 2017 Feb 8;7(18):10660-10667. [Content Brief]