38989-38-7
38989-38-7
Chemical Structure
Coralyne chloride
- CAS. Nr.: 38989-38-7
- Formula:C22H22ClNO4
- Molecular Weight:399.87
IUPAC Name: 2,3,10,11-tetramethoxy-8-methylisoquinolino[3,2-a]isoquinolin-7-ium chloride
InChIKey: PDYBUYVOPAJLKP-UHFFFAOYSA-M
SMILES: CC1=C2C=C(C(OC)=CC2=CC3=C4C=C(C(OC)=CC4=CC=[N+]13)OC)OC.[Cl-]
Biological Activity: Coralyne chloride is a protoberberine alkaloid with potent anti-cancer activities. Coralyne chloride acts as a potent topoisomerase I poison and induces Top I mediated DNA cleavage[2]. Coralyne chloride can be used for preparing coralyne derivatives as DNA binding fluorescent probes[3].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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Coralyne chloride | 98.39% | Coralyne chloride is a protoberberine alkaloid with potent anti-cancer activities. Coralyne chloride acts as a potent topoisomerase I poison and induces Top I mediated DNA cleavage. Coralyne chloride can be used for preparing coralyne derivatives as DNA binding fluorescent probes. | ||||||||||||||||||||
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References
- [2]. D Makhey, et al. Coralyne and related compounds as mammalian topoisomerase I and topoisomerase II poisons. Bioorg Med Chem. 1996 Jun;4(6):781-91. [Content Brief]
- [3]. P M Pithan, et al. 8-Styryl-substituted coralyne derivatives as DNA binding fluorescent probes.RSC Adv. 2017 Feb 8;7(18):10660-10667. [Content Brief]
