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Cat. No.: HY-189117

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HPR-611

HPR-611 is a Tiaramide (HY-W838171) derivative. HPR-611 inhibits the release of histamine, i-LTB₄, and i-LTC₄ in rat peritoneal exudate cells, guinea pig lung fragments, and human lung fragments. HPR-611 can be used for research on bronchial asthma.

For research use only. We do not sell to patients.

CAS No.: 36857-46-2
Formula: C₁₄H₁₅ClN₂O₃S
Molecular Weight:326.80

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

HPR-611 Chemical Structure

CAS No.: 36857-46-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

In Vitro

HPR-611 inhibits allergic histamine release from RPEC^[1].
HPR-611 inhibits allergic histamine release from GPLF^[1].
HPR-611 effectively inhibits the allergic release of histamine, i-LTB₄, and i-LTC₄ in HLF^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 36857-46-2
Molecular Weight 326.80
Formula C₁₄H₁₅ClN₂O₃S
SMILES

O=C1SC2=CC=C(C=C2N1CC(N3CCC(CC3)O)=O)Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Nabe T, et al. A tiaramide derivative, 5-chloro-3-(4-hydroxypiperadinocarbonylmethyl)benzothiazoline-2-one (HPR-611), a potent inhibitor of anaphylactic chemical mediator release--a distinctive feature from disodium cromoglycate. Journal of pharmacobio-dynamics. 1992 Dec;15(12):673-9.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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