2. Gene
  3. TEAD2 - TEA domain transcription factor 2 Gene

TEAD2 - TEA domain transcription factor 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ETF; TEF4; TEF-4; TEAD-2

Gene ID: 8463 | Gene type: protein coding

About TEAD2

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,340,595-49,362,416 (from NCBI)

This gene has 10 transcripts (splice variants), 124 orthologues and 3 paralogues. Ubiquitous expression in endometrium (RPKM 17.4), ovary (RPKM 10.9) and 24 other tissues.

Summary

Enables several functions, including DNA-binding transcription factor activity; disordered domain specific binding activity; and transcription coactivator binding activity. Involved in hippo signaling; positive regulation of transcription, DNA-templated; and protein-containing complex assembly. Located in cytosol and nucleoplasm. Part of TEAD-YAP complex. [provided by Alliance of Genome Resources, Apr 2022]

TEAD2 Products(6)

mRNA Protein Name
NM_001256658.2 NP_001243587.1 transcriptional enhancer factor TEF-4 isoform 1
NM_001256659.2 NP_001243588.1 transcriptional enhancer factor TEF-4 isoform 1
NM_001256660.2 NP_001243589.1 transcriptional enhancer factor TEF-4 isoform 2
NM_001256661.2 NP_001243590.1 transcriptional enhancer factor TEF-4 isoform 2
NM_001256662.2 NP_001243591.1 transcriptional enhancer factor TEF-4 isoform 4
NM_003598.2 NP_003589.1 transcriptional enhancer factor TEF-4 isoform 3

TEAD2 Protein Structure

TEA

TEA: TEA/ATTS domain family (20 - 439)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 447 a.a.
Protein Preferred Names Protein Names

transcriptional enhancer factor TEF-4

TEA domain family member 2

Related Diseases

Diseases Alias
Sveinsson Chorioretinal Atrophy

SCRA

Atrophia Areata

Helicoid Peripapillary Chorioretinal Degeneration

Hpcd

Aa

Peripapillary Chorioretinal Degeneration, Icelandic Type

Helicoidal Peripapillary Chorioretinal Degeneration

Atrophy, Chorioretinal, Sveinsson
Spastic Paraplegia 24, Autosomal Recessive

SPG24

Spastic Paraplegia 24

Hereditary Spastic Paraplegia 24

Autosomal Recessive Spastic Paraplegia Type 24

Autosomal Recessive Spastic Paraplegia 24
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B1221 Flufenamic acid 99.85% Unkown
Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-139330 MGH-CP1 Inducer 99.21% Unkown
HY-B1221S1 Flufenamic acid-13C6 / Unkown
HY-B1221S Flufenamic acid-d4 / Unkown
HY-RS14343 TEAD2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TEAD2 VGNC VGNC:47229
Mus musculus TEAD2 MGD MGI:104904
Bos taurus TEAD2 VGNC VGNC:35725
Felis catus TEAD2 VGNC VGNC:66054
Rattus norvegicus TEAD2 RGD RGD:1593252
Macaca mulatta TEAD2 VGNC VGNC:78302