TEAD2 - TEA domain transcription factor 2 Gene

Also Known as ETF; TEF4; TEF-4; TEAD-2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8463

About TEAD2

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,340,595-49,362,416 (from NCBI)

This gene has 10 transcripts (splice variants), 124 orthologues and 3 paralogues. Ubiquitous expression in endometrium (RPKM 17.4), ovary (RPKM 10.9) and 24 other tissues.

Summary

Enables several functions, including DNA-binding transcription factor activity; disordered domain specific binding activity; and transcription coactivator binding activity. Involved in hippo signaling; positive regulation of transcription, DNA-templated; and protein-containing complex assembly. Located in cytosol and nucleoplasm. Part of TEAD-YAP complex. [provided by Alliance of Genome Resources, Apr 2022]

TEAD2 Products (6)

mRNA	Protein	Name
NM_001256658.2	NP_001243587.1	transcriptional enhancer factor TEF-4 isoform 1
NM_001256659.2	NP_001243588.1	transcriptional enhancer factor TEF-4 isoform 1
NM_001256660.2	NP_001243589.1	transcriptional enhancer factor TEF-4 isoform 2
NM_001256661.2	NP_001243590.1	transcriptional enhancer factor TEF-4 isoform 2
NM_001256662.2	NP_001243591.1	transcriptional enhancer factor TEF-4 isoform 4
NM_003598.2	NP_003589.1	transcriptional enhancer factor TEF-4 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	18579750	GOA
enables DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	20368466	GOA
enables disordered domain specific binding	IMP IMP: Inferred from mutant phenotype	20368466	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18579750	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA
enables transcription coactivator binding	IPI IPI: Inferred from physical interaction	20368466	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in hippo signaling	IDA IDA: Inferred from direct assay	18579750	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	20368466	GOA
involved in protein-containing complex assembly	IMP IMP: Inferred from mutant phenotype	20368466	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of TEAD-YAP complex	IDA IDA: Inferred from direct assay	20368466	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TEAD2 Protein Structure

TEA

0
100
200
300
400
447 a.a.

Protein Preferred Names	Protein Names
transcriptional enhancer factor TEF-4	TEA domain family member 2

TEAD2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TEAD2	Q15562	BCL2L15	Homo sapiens	Q5TBC7	Anti Tag CoIP	25416956
Intra	TEAD2	Q15562	BCL2L15	Homo sapiens	Q5TBC7	Y2H Array	25416956
Intra	TEAD2	Q15562	YAP1	Homo sapiens	P46937	NMR	20368466
Intra	TEAD2	Q15562	YAP1	Homo sapiens	P46937	Anti Tag CoIP	33961781
Intra	TEAD2	Q15562	YAP1	Homo sapiens	P46937	Pull Down	20368466
Intra	TEAD2	Q15562	YAP1	Homo sapiens	P46937	ITC	20368466
Intra	TEAD2	Q15562	YAP1	Homo sapiens	P46937	BioID	35140242
Intra	TEAD2	Q15562	USF2	Homo sapiens	Q15853	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

TEAD2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P811142	TEAD2 Antibody	WB, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P87103	TEAD2 Antibody (YA6796)	WB	Human, Mouse

Related Diseases

Diseases	Alias
Sveinsson Chorioretinal Atrophy	SCRA Atrophia Areata Helicoid Peripapillary Chorioretinal Degeneration Hpcd Aa Peripapillary Chorioretinal Degeneration, Icelandic Type Helicoidal Peripapillary Chorioretinal Degeneration Atrophy, Chorioretinal, Sveinsson
Spastic Paraplegia 24, Autosomal Recessive	SPG24 Spastic Paraplegia 24 Hereditary Spastic Paraplegia 24 Autosomal Recessive Spastic Paraplegia Type 24 Autosomal Recessive Spastic Paraplegia 24

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B1221	Flufenamic acid		99.93%	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-172113	H122		98.33%	Phase 4

Pre-clinical Phase

Bioactive Molecules (15)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-139330	MGH-CP1	Inducer	99.56%	Unkown
HY-147135	MYF-03-69		98.11%	Unkown
HY-158342	PROTAC TEAD degrader-1	Degrader	99.82%	Unkown
HY-161569	TEAD-IN-11	Inhibitor	99.82%	Unkown
HY-B1221S1	Flufenamic acid-13C6		/	Unkown
HY-186117	KG-FP-003	Degrader	/	Unkown
HY-161568	TEAD-IN-10	Inhibitor	/	Unkown
HY-173139	TEAD-IN-19	Inhibitor	/	Unkown
HY-181534	PROTAC TEAD1/IAP degrader-1	Degrader	/	Unkown
HY-183753	LC-TD-05		/	Unkown
HY-184225	PROTAC TEAD degrader-3	Degrader	/	Unkown
HY-B1221S	Flufenamic acid-d4		/	Unkown
HY-RS14343	TEAD2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19240	Tead2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25729	Tead2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TEAD2	VGNC	VGNC:47229
Mus musculus	TEAD2	MGD	MGI:104904
Bos taurus	TEAD2	VGNC	VGNC:35725
Felis catus	TEAD2	VGNC	VGNC:66054
Rattus norvegicus	TEAD2	RGD	RGD:1593252
Macaca mulatta	TEAD2	VGNC	VGNC:78302
Others	TEAD2	NCBI